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BET inhibition revealed varying MYC dependency mechanisms independent of gene alterations in aggressive B-cell lymphomas.

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第一作者： Loris,Delrieu

第一单位： Univ. Grenoble Alpes, Inserm, CNRS, Institute for Advanced Biosciences, Grenoble, France.

作者： Loris,Delrieu ^[1] ; Sieme,Hamaidia ^[2] ; Emilie,Montaut ^[2] ; Andrea Cecilia,Garcia-Sandoval ^[1] ; Camille,Teste ^[1] ; Patricia,Betton-Fraisse ^[1] ; Thierry,Bonnefoix ^[2] ; Sylvain,Carras ^[3] ; Rémy,Gressin ^[4] ; Christine,Lefebvre ^[5] ; Jérôme,Govin ^[1] ; Anouk,Emadali ^[6]

作者单位： Univ. Grenoble Alpes, Inserm, CNRS, Institute for Advanced Biosciences, Grenoble, France. ^[1] Univ. Grenoble Alpes, Inserm, CNRS, Institute for Advanced Biosciences, Grenoble, France.;Recherche and Innovation Unit, Grenoble Alpes University Hospital, Grenoble, France. ^[2] Univ. Grenoble Alpes, Inserm, CNRS, Institute for Advanced Biosciences, Grenoble, France.;Hematology, Oncogenetics and Immunology Unit, Grenoble Alpes University Hospital, Grenoble, France.;Department of Clinical Hematology, Grenoble Alpes University Hospital, Grenoble, France. ^[3] Univ. Grenoble Alpes, Inserm, CNRS, Institute for Advanced Biosciences, Grenoble, France.;Department of Clinical Hematology, Grenoble Alpes University Hospital, Grenoble, France. ^[4] Univ. Grenoble Alpes, Inserm, CNRS, Institute for Advanced Biosciences, Grenoble, France.;Hematology, Oncogenetics and Immunology Unit, Grenoble Alpes University Hospital, Grenoble, France. ^[5] Univ. Grenoble Alpes, Inserm, CNRS, Institute for Advanced Biosciences, Grenoble, France. anouk.emadali@univ-grenoble-alpes.fr.;Recherche and Innovation Unit, Grenoble Alpes University Hospital, Grenoble, France. anouk.emadali@univ-grenoble-alpes.fr. ^[6]

关键词 B-cell lymphoma BET inhibition MYC Oncogene dependency