Sex-specific fear acquisition following early life stress is linked to amygdala and hippocampal purine and glutamate metabolism.

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作者： Joeri,Bordes ^[1] ; Thomas,Bajaj ^[2] ; Lucas,Miranda ^[3] ; Lotte,van Doeselaar ^[4] ; Lea Maria,Brix ^[4] ; Sowmya,Narayan ^[4] ; Huanqing,Yang ^[1] ; Shiladitya,Mitra ^[1] ; Veronika,Kovarova ^[4] ; Margherita,Springer ^[1] ; Karin,Kleigrewe ^[5] ; Bertram,Müller-Myhsok ^[6] ; Nils C,Gassen ^[2] ; Mathias V,Schmidt ^[7]

作者单位： Research Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, 80804, Munich, Germany. ^[1] Neurohomeostasis Research Group, Department of Psychiatry and Psychotherapy, Bonn Clinical Center, University of Bonn, 53127, Bonn, Germany. ^[2] Research Group Statistical Genetics, Max Planck Institute of Psychiatry, 80804, Munich, Germany.;International Max Planck Research School for Translational Psychiatry (IMPRS-TP), 80804, Munich, Germany. ^[3] Research Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, 80804, Munich, Germany.;International Max Planck Research School for Translational Psychiatry (IMPRS-TP), 80804, Munich, Germany. ^[4] Bavarian Center for Biomolecular Mass Spectrometry, TUM School of Life Sciences, Technical University of Munich, Freising, Germany. ^[5] Research Group Statistical Genetics, Max Planck Institute of Psychiatry, 80804, Munich, Germany. ^[6] Research Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, 80804, Munich, Germany. mschmidt@psych.mpg.de. ^[7]

主题词动物(Animals);恐惧(Fear);女(雌)性(Female);海马(Hippocampus);男(雄)性(Male);谷氨酸(Glutamic Acid);小鼠(Mice);应激, 心理学(Stress, Psychological);杏仁核(Amygdala);嘌呤类(Purines);小鼠, 近交C57BL(Mice, Inbred C57BL);性征(Sex Characteristics);性别因素(Sex Factors);应激障碍, 创伤后(Stress Disorders, Post-Traumatic)

DOI 10.1038/s42003-024-07396-8

PMID 39702524

发布时间 2025-01-04

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Communications biology

2024年7卷1期

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Sex-specific fear acquisition following early life stress is linked to amygdala and hippocampal purine and glutamate metabolism.

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Sex-specific fear acquisition following early life stress is linked to amygdala and hippocampal purine and glutamate metabolism.

Communications biology

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Communications biology

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