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Efficacy of CTLA-4 checkpoint therapy is dependent on IL-21 signaling to mediate cytotoxic reprogramming of PD-1<sup>+</sup>CD8<sup>+</sup> T cells.

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作者单位: Faculty of Medicine, Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology and Infectious Disease, University Medical Center Freiburg, Freiburg, Germany. [1] Faculty of Medicine, Clinic for Internal Medicine I, Hematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany. [2] Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA. [3] Department of Dermatology and Venereology, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany. [4] Department of Rheumatology and Clinical Immunology, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany. [5] Faculty of Medicine, Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology and Infectious Disease, University Medical Center Freiburg, Freiburg, Germany.;Department of Gastroenterology and Hepatology, University Hospital Cologne, Faculty of Medicine, University of Cologne, Cologne, Germany. [6] Institute of Medical Bioinformatics and Systems Medicine, University Medical Center Freiburg, Freiburg, Germany. [7] Faculty of Medicine, Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology and Infectious Disease, University Medical Center Freiburg, Freiburg, Germany. bertram.bengsch@uniklinik-freiburg.de.;Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany. bertram.bengsch@uniklinik-freiburg.de.;German Cancer Consortium (DKTK) Heidelberg, Germany, Partner Site Freiburg, Freiburg, Germany. bertram.bengsch@uniklinik-freiburg.de. [8]
DOI 10.1038/s41590-024-02027-0
PMID 39702858
发布时间 2025-01-03
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