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Efficacy of CTLA-4 checkpoint therapy is dependent on IL-21 signaling to mediate cytotoxic reprogramming of PD-1+CD8+ T cells.

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第一作者： Zhen,Zhang

第一单位： Faculty of Medicine, Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology and Infectious Disease, University Medical Center Freiburg, Freiburg, Germany.

作者： Zhen,Zhang ^[1] ; Marlene,Langenbach ^[2] ; Sagar,Sagar ^[1] ; Viktor,Fetsch ^[2] ; Jonas,Stritzker ^[1] ; Elizabeth,Severa ^[3] ; Ke,Meng ^[1] ; Frances,Winkler ^[1] ; Nisha,Rana ^[1] ; Katharina,Zoldan ^[1] ; Ira,Godbole ^[1] ; Sabrina,Solis ^[3] ; Jeffrey S,Weber ^[3] ; David,Rafei-Shamsabadi ^[4] ; Saskia,Lehr ^[4] ; Rebecca,Diehl ^[4] ; Ana Cecilia,Venhoff ^[5] ; Reinhard E,Voll ^[5] ; Nico,Buettner ^[1] ; Christoph,Neumann-Haefelin ^[6] ; Tobias,Boettler ^[1] ; Maike,Hofmann ^[1] ; Melanie,Boerries ^[7] ; Frank,Meiss ^[4] ; Robert,Zeiser ^[2] ; Robert,Thimme ^[1] ; Ramin S,Herati ^[3] ; Bertram,Bengsch ^[8]

作者单位： Faculty of Medicine, Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology and Infectious Disease, University Medical Center Freiburg, Freiburg, Germany. ^[1] Faculty of Medicine, Clinic for Internal Medicine I, Hematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany. ^[2] Department of Medicine, New York University Grossman School of Medicine, New York, NY, USA. ^[3] Department of Dermatology and Venereology, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany. ^[4] Department of Rheumatology and Clinical Immunology, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany. ^[5] Faculty of Medicine, Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology and Infectious Disease, University Medical Center Freiburg, Freiburg, Germany.;Department of Gastroenterology and Hepatology, University Hospital Cologne, Faculty of Medicine, University of Cologne, Cologne, Germany. ^[6] Institute of Medical Bioinformatics and Systems Medicine, University Medical Center Freiburg, Freiburg, Germany. ^[7] Faculty of Medicine, Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology and Infectious Disease, University Medical Center Freiburg, Freiburg, Germany. bertram.bengsch@uniklinik-freiburg.de.;Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany. bertram.bengsch@uniklinik-freiburg.de.;German Cancer Consortium (DKTK) Heidelberg, Germany, Partner Site Freiburg, Freiburg, Germany. bertram.bengsch@uniklinik-freiburg.de. ^[8]