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Synergistic Anticancer Strategy Targeting ECM Stiffness: Integration of Matrix Softening and Mechanical Signal Transduction Blockade in Primary Liver Cancers.

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第一作者： Zefeng,Shen

第一单位： Zhejiang Key Laboratory of Multi-omics Precision Diagnosis and Treatment of Liver Diseases, Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310016, China.;Zhejiang Minimal Invasive Diagnosis and Treatment Technology Research Center of Severe Hepatobiliary Disease, Zhejiang Research and Development Engineering Laboratory of Minimally Invasive Technology and Equipment, Hangzhou, Zhejiang, 310016, China.;Zhejiang University Cancer Center, Hangzhou, Zhejiang, 310058, China.;Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, Zhejiang, 311121, China.

作者： Zefeng,Shen ^[1] ; Liye,Tao ^[1] ; Yali,Wang ^[1] ; Yiwei,Zhu ^[2] ; Haoyu,Pan ^[1] ; Yijun,Li ^[3] ; Shi,Jiang ^[4] ; Junhao,Zheng ^[1] ; Jingwei,Cai ^[1] ; Yang,Liu ^[1] ; Kainan,Lin ^[1] ; Shihao,Li ^[1] ; Yifan,Tong ^[1] ; Liqing,Shangguan ^[2] ; Junjie,Xu ^[1] ; Xiao,Liang ^[5]

作者单位： Zhejiang Key Laboratory of Multi-omics Precision Diagnosis and Treatment of Liver Diseases, Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310016, China.;Zhejiang Minimal Invasive Diagnosis and Treatment Technology Research Center of Severe Hepatobiliary Disease, Zhejiang Research and Development Engineering Laboratory of Minimally Invasive Technology and Equipment, Hangzhou, Zhejiang, 310016, China.;Zhejiang University Cancer Center, Hangzhou, Zhejiang, 310058, China.;Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, Zhejiang, 311121, China. ^[1] Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310016, China. ^[2] Department of Orthopaedic Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China. ^[3] Department of Thyroid and Breast Surgery, Ningbo First Hospital, Zhejiang University, Ningbo, Zhejiang, 315010, China. ^[4] Zhejiang Key Laboratory of Multi-omics Precision Diagnosis and Treatment of Liver Diseases, Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310016, China.;Zhejiang Minimal Invasive Diagnosis and Treatment Technology Research Center of Severe Hepatobiliary Disease, Zhejiang Research and Development Engineering Laboratory of Minimally Invasive Technology and Equipment, Hangzhou, Zhejiang, 310016, China.;Zhejiang University Cancer Center, Hangzhou, Zhejiang, 310058, China.;Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, Zhejiang, 311121, China.;School of Medicine, Shaoxing University, Shaoxing, Zhejiang, 312000, China. ^[5]

关键词 extracellular matrix stiffness primary liver cancers synergistic anticancer strategy