Identification and characterization of the functional tetrameric UDP-glucose pyrophosphorylase from <i>Klebsiella pneumoniae</i>.

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作者： Isabel,Ramón Roth ^[1] ; Pavel,Kats ^[2] ; Timm,Fiebig ^[1] ; Françoise,Routier ^[1] ; Roman,Fedorov ^[3] ; Larissa,Dirr ^[4] ; Jana I,Führing ^[1]

作者单位： Institute of Clinical Biochemistry, Hannover Medical School, Hannover, Germany. ^[1] Institute for Biophysical Chemistry, Hannover Medical School, Hannover, Germany. ^[2] Institute for Biophysical Chemistry, Hannover Medical School, Hannover, Germany.;Division for Structural Biochemistry, Hannover Medical School, Hannover, Germany. ^[3] Institute for Biomedicine and Glycomics, Griffith University, Gold Coast, Southport, Australia. ^[4]

关键词 AlphaFold model Klebsiella pneumoniae UDP-glucose pyrophosphorylase antibacterial drug target dimerization enzymatic mechanism galF galU nucleotidyltransferase protein oligomerization structure-function relationship tetramerization

主题词 UTP-葡糖-1-磷酸尿苷酰转移酶(UTP-Glucose-1-Phosphate Uridylyltransferase);肺炎克雷伯菌(Klebsiella pneumoniae);细菌蛋白质类(Bacterial Proteins);毒力因子类(Virulence Factors)

DOI 10.1128/mbio.02071-24

PMID 39704542

发布时间 2025-02-07

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