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De-escalating and discontinuing disease-modifying therapies in multiple sclerosis.

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第一作者: Géraldine,Androdias
第一单位: Service de neurologie, sclérose en plaques, pathologies de la myéline et neuro-inflammation, Centre de Ressources, Recherche et Compétence sur la Sclérose en Plaques, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, 69677 Lyon-Bron, France.;Clinique de la Sauvegarde, Ramsay Santé, Lyon 69009, France.
作者单位: Service de neurologie, sclérose en plaques, pathologies de la myéline et neuro-inflammation, Centre de Ressources, Recherche et Compétence sur la Sclérose en Plaques, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, 69677 Lyon-Bron, France.;Clinique de la Sauvegarde, Ramsay Santé, Lyon 69009, France. [1] Department of Neurology with Institute of Translational Neurology, University and University Hospital Münster, Münster 48149, Germany. [2] Department of Neurology, Multiple Sclerosis Center, Pitié-Salpêtrière Hospital, AP-HP, Paris 75013, France. [3] Departmente NEUROFARBA, University of Florence, Florence 50139, Italy.;IRCCS Fondazione Don Carlo Gnocchi, Florence 50143, Italy. [4] Department of Neurology, University Hospital of Marseille, Marseille 13005, France.;Centre de Résonance Magnétique Biologique et Médicale (CRMBM), CNRS, Aix Marseille University, Marseille Cedex 5 13385, France. [5] Department of Neurology, Erasmus Medical Center, Rotterdam 3015 GD, The Netherlands. [6] Department of Neurology, Medical University of Vienna, Vienna 1090, Austria.;Comprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna, Vienna 1090, Austria. [7] Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne 3004, Australia.;Department of Neurology, Alfred Health, Melbourne 3004, Australia. [8] Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.;National Institute for Health and Care Research (NIHR), University College London Hospitals (UCLH) Biomedical Research Centre, London WC1B 5EH, UK. [9] Department of Neurology, Multiple Sclerosis Centre of Catalonia (Cemcat), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona 08035, Spain. [10] Departments of Neurology and Biomedicine, University Hospital Basel, Basel 4031, Switzerland.;Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Basel, Basel 4031, Switzerland. [11] Department of Neurology, Medical University of Innsbruck, Innsbruck 6020, Austria. [12] Department of Neurology, University Hospital of Rennes, Rennes 35033, France.;CIC-P 1414 INSERM, University Hospital of Rennes, Rennes 35033, France. [13] Department of Neurology, Medical University of Graz, Graz 8010, Austria. [14] NMO service, Department of Neurology, Oxford University Hospitals, Oxford OX3 9DU, UK.;Nuffield Department of Clinical Neurosciences, Oxford University, Oxford OX3 9DU, UK. [15] Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Basel, Basel 4031, Switzerland.;Neurology Clinic and Policlinic, Departments of Medicine, Clinical Research and Biomedical Engineering, University Hospital Basel and University of Basel, Basel 4031, Switzerland.;Translational Imaging in Neurology (ThINk) Basel, Department of Biomedical Engineering, University Hospital Basel and University of Basel, Basel 4031, Switzerland. [16] Queen Square MS Centre, Department of Neuroinflammation, Faculty of Brain Sciences, UCL Queen Square Institute of Neurology, UCL, London WC1N 3BG, UK.;Department of Neurology, Great Ormond Street Hospital for Children, London WC1N 3JH, UK. [17] Department of Neurology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf 40225, Germany.;Brain and Mind Center, Medical Faculty, University of Sydney, Sydney, NSW 2050, Australia.;Department of Neurology, Palacky University Olomouc, Olomouc 77900, Czech Republic. [18] School of Health Sciences, College of Medicine, Nursing and Health Sciences, University of Galway, Galway H91 TK33, UK. [19] Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Genoa 16132, Italy.;MS Center, IRCCS Ospedale Policlinico San Martino, Genoa 16132, Italy. [20] Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Basel, Basel 4031, Switzerland.;Departments of Head Spine and Neuromedicine, Biomedicine, Research and Biomedical Engineering, University Hospital Basel and University of Basel, Basel 4031, Switzerland. [21] Tampere University Hospital, Department of Neurology, Tampere 33520, Finland.;University of Eastern Finland, Faculty of Social and Welfare Management, Kuopio 70211, Finland. [22] Neurology Department, Los Angeles Medical Center, Southern California Permanente Medical Group, Kaiser Permanente, Los Angeles, CA 90027, USA. [23] Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital-Rigshospitalet, Glostrup 2600, Denmark.;Danish Multiple Sclerosis Registry, Copenhagen University Hospital-Rigshospitalet, Glostrup 2600, Denmark.;Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2100, Denmark. [24] Service de neurologie, sclérose en plaques, pathologies de la myéline et neuro-inflammation, Centre de Ressources, Recherche et Compétence sur la Sclérose en Plaques, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, 69677 Lyon-Bron, France.;Centre de Référence des Maladies Inflammatoires Rares du Cerveau et de la Moelle, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Lyon-Bron 69677, France. [25] Department of Neurology, Multiple Sclerosis Centre of Catalonia (Cemcat), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona 08035, Spain.;Faculty of Medicine, UVIC-UCC Universitat Central de Catalunya, Vic 08500, Spain. [26] Department of Neurology, University of Warmia and Mazury, Olsztyn 10719, Poland. [27] Department of Neurology, Johns Hopkins University School of Medicine, Baltimore 21287, MD, USA. [28] Division of Neurology, Department of Medicine, St. Michael's Hospital, University of Toronto, Toronto M5B1W8, Canada. [29] Department of Neurology, Hospital Clinico San Carlos, IdISSC, Madrid 28040, Spain.;Departamento de Medicina, Facultad de Medicina, Universidad Complutense de Madrid (UCM), 28040 Madrid, Spain. [30] Department of Clinical Neuroscience, Karolinska Institute, 171 77 Stockholm, Sweden.;Department of Neurology, Karolinska University Hospital, S171 76 Stockholm, Sweden. [31] MS Unit, S. Camillo-Forlanini Hospital, Rome 00152, Italy. [32] Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital-Rigshospitalet, Glostrup 2600, Denmark.;Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2100, Denmark. [33] Department of Neurology, University of Warmia and Mazury, Olsztyn 10719, Poland.;Center of Neurology, Lodz 90-324, Poland. [34] Clinical Neuroimmunology Unit & MS Clinic, Department Of Neurology, Istanbul University Cerrahpasa School Of Medicine, Istanbul 34098, Turkey. [35] Department of Neurology, University Hospital of Wales, Cardiff CF14 4XW, UK.;Division of Psychological Medicine and Clinical Neuroscience, Cardiff University, Cardiff CF14 4XN, UK. [36] Department of Neurology, Cliniques Universitaires Saint-Luc, UCLouvain, Brussels 1200, Belgium. [37] Service de neurologie, sclérose en plaques, pathologies de la myéline et neuro-inflammation, Centre de Ressources, Recherche et Compétence sur la Sclérose en Plaques, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, 69677 Lyon-Bron, France.;Université de Lyon, Université Claude Bernard Lyon 1, Lyon-Villeurbanne 69100, France.;Observatoire Français de la Sclérose en Plaques, Centre de Recherche en Neurosciences de Lyon, INSERM 1028 et CNRS UMR 5292, Lyon-Bron 69677, France.;Eugène Devic EDMUS Foundation against multiple sclerosis, Bron 69500, France. [38] Jacobs School of Medicine and Biomedical Sciences, SUNY University at Buffalo, UB Neurology, Buffalo 14203, NY, USA. [39] Department of Neurology, Focus Program Translational Neuroscience (FTN), and Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University, Mainz 55131, Germany. [40] Department of Neurology, Karolinska University Hospital, S171 76 Stockholm, Sweden. [41] Department of Neurology, Multiple Sclerosis Center, Pitié-Salpêtrière Hospital, AP-HP, Paris 75013, France.;Sorbonne Université, Paris Brain Institute, ICM, Inserm, CNRS, Hôpital de la Pitié Salpêtrière AP-HP, Paris 75013, France. [42]
DOI 10.1093/brain/awae409
PMID 39707906
发布时间 2025-05-25
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Brain : a journal of neurology

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