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snRNA-seq stratifies multiple sclerosis patients into distinct white matter glial responses.

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作者单位: Roche Pharma Research and Early Development, Neuroscience and Rare Diseases, Roche Innovation Center, Basel, Switzerland. Electronic address: will.macnair@roche.com. [1] Roche Pharma Research and Early Development, Neuroscience and Rare Diseases, Roche Innovation Center, Basel, Switzerland. [2] Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177 Stockholm, Sweden. [3] Institute for Stroke and Dementia Research (ISD), Klinikum der Universität München, Ludwig-Maximilians Universität, Munich, Germany; Munich Cluster of Systems Neurology (SyNergy), Munich, Germany. [4] Centre for Regenerative Medicine, Institute for Regeneration and Repair, MS Society Edinburgh Centre for MS Research, The University of Edinburgh, 5 Little France Drive, Edinburgh EH16 4UU, UK. [5] Roche Pharma Research and Early Development (pRED), Pharmaceutical Sciences, Pathology and Applied Safety Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070 Basel, Switzerland. [6] Department of Neurobiology and Aging, Biomedical Primate Research Centre, Rijswijk, the Netherlands. [7] Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy. [8] Department of Molecular Life Sciences and SIB Swiss Institute of Bioinformatics, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. [9] Faculty of Medicine and Health Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK. Electronic address: cffc@uea.ac.uk. [10] Laboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177 Stockholm, Sweden. Electronic address: goncalo.castelo-branco@ki.se. [11] Centre for Regenerative Medicine, Institute for Regeneration and Repair, MS Society Edinburgh Centre for MS Research, The University of Edinburgh, 5 Little France Drive, Edinburgh EH16 4UU, UK. Electronic address: anna.williams@ed.ac.uk. [12] Roche Pharma Research and Early Development, Neuroscience and Rare Diseases, Roche Innovation Center, Basel, Switzerland. Electronic address: dheeraj21malhotra@gmail.com. [13]
DOI 10.1016/j.neuron.2024.11.016
PMID 39708806
发布时间 2025-02-07
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Neuron

Neuron

2025年113卷3期

396-410.e9页

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