The N-degron pathway mediates the autophagic degradation of cytosolic mitochondrial DNA during sterile innate immune responses.

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第一作者： Chan Hoon,Jung

第一单位： Cellular Degradation Biology Center and Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea.

作者： Chan Hoon,Jung ^[1] ; Yoon Jee,Lee ^[1] ; Eun Hye,Cho ^[1] ; Gee Eun,Lee ^[1] ; Sung Tae,Kim ^[2] ; Ki Sa,Sung ^[3] ; Daeho,Kim ^[4] ; Dong Hyun,Kim ^[5] ; Yeon Sung,Son ^[6] ; Jin-Hyun,Ahn ^[7] ; Dohyun,Han ^[8] ; Yong Tae,Kwon ^[9]

作者单位： Cellular Degradation Biology Center and Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea. ^[1] Regeners, Inc., BVC 112, 125 Gwahak-ro, Yuseong-gu, Daejeon, Republic of Korea. ^[2] Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. ^[3] Department of Biochemistry, Case Western Reserve University, Cleveland, OH 44106, USA. ^[4] Cancer Metastasis Brach, Division of Cancer Biology, National Cancer Center, Goyang-si Gyeonggi-do 10408, Republic of Korea. ^[5] Cellular Degradation Biology Center and Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea; Neuroscience Research Institute, Medical Research Center, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea. ^[6] Department of Microbiology, Sungkyunkwan University School of Medicine, Suwon 16419, Republic of Korea. ^[7] Department of Transdisciplinary Medicine, Seoul National University Hospital, Seoul 03082, Republic of Korea; Department of Medicine, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea. Electronic address: hdh03@snu.ac.kr. ^[8] Cellular Degradation Biology Center and Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea; Convergence Research Center for Dementia, Seoul National University Medical Research Center, Seoul 110-799, Republic of Korea; AUTOTAC Bio, Inc., Changkkyunggung-ro 254, Jongno-gu, Seoul 03077, Republic of Korea; Ischemic/Hypoxic Disease Institute, College of Medicine, Seoul National University, Seoul 110-799, Republic of Korea. Electronic address: yok5@snu.ac.kr. ^[9]

关键词 ATE1 CP: Immunology DNA-PK KU70 R-BiP autophagy mitochondrial DNA proteasomal dysfunction sterile immune response the N-degron pathway type I interferon