Pan-KRAS inhibitors BI-2493 and BI-2865 display potent anti-tumor activity in tumors with KRAS wild-type allele amplification.

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第一作者： Antonio,Tedeschi

第一单位： Boehringer Ingelheim (Austria), Vienna, Austria.

作者： Antonio,Tedeschi ^[1] ; Fiorella,Schischlik ^[1] ; Francesca,Rocchetti ^[2] ; Johannes,Popow ^[1] ; Florian,Ebner ^[3] ; Daniel,Gerlach ^[1] ; Antonia,Geyer ^[4] ; Valeria,Santoro ^[2] ; Andrew S,Boghossian ^[5] ; Matthew G,Rees ^[5] ; Melissa M,Ronan ^[5] ; Jennifer A,Roth ^[5] ; Jesse,Lipp ^[2] ; Matthias,Samwer ^[2] ; Michael,Gmachl ^[1] ; Norbert,Kraut ^[6] ; Mark,Pearson ^[4] ; Dorothea,Rudolph ^[1]

作者单位： Boehringer Ingelheim (Austria), Vienna, Austria. ^[1] Boehringer Ingelheim (Austria), Austria. ^[2] Boehringer Ingelheim (Austria), Vienna, Vienna, Austria. ^[3] Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria. ^[4] Broad Institute, Cambridge, MA, United States. ^[5] Discovery Research, Boehringer Ingelheim RCV GmbH & Co KG, Vienna, Austria. ^[6]

DOI 10.1158/1535-7163.MCT-24-0386

PMID 39711431

发布时间 2024-12-23

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Molecular cancer therapeutics

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Pan-KRAS inhibitors BI-2493 and BI-2865 display potent anti-tumor activity in tumors with KRAS wild-type allele amplification.

Molecular cancer therapeutics

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Molecular cancer therapeutics

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Pan-KRAS inhibitors BI-2493 and BI-2865 display potent anti-tumor activity in tumors with KRAS wild-type allele amplification.

Molecular cancer therapeutics

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Molecular cancer therapeutics

相关期刊

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