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首页> Journal of medical virology> A Novel Circular Delta-XBB15 RBD Dimeric Protein Subunit Vaccine Mediated by Split Intein Elicits an Immune Response and Protection Against Multiple SARS-CoV-2 Variants in Mice.

A Novel Circular Delta-XBB15 RBD Dimeric Protein Subunit Vaccine Mediated by Split Intein Elicits an Immune Response and Protection Against Multiple SARS-CoV-2 Variants in Mice.

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作者： Kangyin,Li ^[1] ; Yan,Wu ^[2] ; Hongqing,Zhang ^[2] ; Shaohong,Chen ^[1] ; Bihao,Wu ^[1] ; Tingting,Li ^[3] ; Entao,Li ^[4] ; Feiyang,Luo ^[3] ; Aishun,Jin ^[3] ; Bo,Zhang ^[2] ; Yanan,Zhang ^[2] ; Rui,Gong ^[2] ; Huajun,Zhang ^[2] ; Sandra,Chiu ^[4]

作者单位： Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.;University of the Chinese Academy of Sciences, Beijing, China. ^[1] Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China. ^[2] Department of Immunology, School of Basic Medical Sciences, Chongqing Medical University, Chongqing, China.;Chongqing Key Laboratory of Tumor Immune Regulation and Immune Intervention, Chongqing, China. ^[3] Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.;Key Laboratory of Anhui Province for Emerging and Reemerging Infectious Diseases, Hefei, China. ^[4]

关键词 RBD SARS‐CoV‐2 circular protein intein subunit protein vaccine

主题词动物(Animals);小鼠(Mice);抗体, 中和(Antibodies, Neutralizing);疫苗, 亚单位(Vaccines, Subunit);抗体, 病毒(Antibodies, Viral);内含肽类(Inteins);小鼠, 近交BALB C(Mice, Inbred BALB C);人类(Humans);女(雌)性(Female);免疫, 细胞(Immunity, Cellular)

DOI 10.1002/jmv.70134

PMID 39711477

发布时间 2024-12-23

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Journal of medical virology

Journal of medical virology

2024年96卷12期

e70134页

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