首页> Frontiers in oncology> Direct comparison of an ultrasensitive real-time PCR assay with droplet digital PCR for the detection of <i>PIK3CA</i> hotspot mutations in primary tumors, plasma cell-free DNA and paired CTC-derived gDNAs.

Direct comparison of an ultrasensitive real-time PCR assay with droplet digital PCR for the detection of <i>PIK3CA</i> hotspot mutations in primary tumors, plasma cell-free DNA and paired CTC-derived gDNAs.

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第一作者： Stavroula,Smilkou

第一单位： Analysis of Circulating Tumor Cells, Laboratory of Analytical Chemistry, Department of Chemistry, University of Athens, Athens, Greece.

作者： Stavroula,Smilkou ^[1] ; Loukas,Kaklamanis ^[2] ; Ioanna,Balgouranidou ^[3] ; Helena,Linardou ^[4] ; Alkistis Maria,Papatheodoridi ^[5] ; Flora,Zagouri ^[5] ; Evangelia,Razis ^[6] ; Stylianos,Kakolyris ^[3] ; Amanda,Psyrri ^[7] ; Christos,Papadimitriou ^[8] ; Athina,Markou ^[1] ; Evi,Lianidou ^[1]

作者单位： Analysis of Circulating Tumor Cells, Laboratory of Analytical Chemistry, Department of Chemistry, University of Athens, Athens, Greece. ^[1] Department of Pathology, Onassis Cardiac Surgery Center, Athens, Greece. ^[2] Department of Medical Oncology, University General Hospital of Alexandroupolis, Alexandroupolis, Greece. ^[3] Oncology Unit, Metropolitan Hospital, Athens, Greece. ^[4] Department of Clinical Therapeutics, School of Medicine, Alexandra Hospital, National and Kapodistrian University of Athens, Athens, Greece. ^[5] Third Department of Medical Oncology, Hygeia Hospital, Athens, Greece. ^[6] Section of Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Attikon University Hospital, Athens, Greece. ^[7] Oncology Unit, 2nd Department of Surgery, School of Medicine, Aretaieio Hospital, National and Kapodistrian University of Athens, Athens, Greece. ^[8]

关键词 DNA melting curve analysis PIK3CA mutations breast cancer circulating tumor cells droplet digital PCR liquid biopsy plasma cell-free DNA ultrasensitive molecular assay

DOI 10.3389/fonc.2024.1435559

PMID 39711963

发布时间 2025-01-04

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