Impairment of lipid homeostasis causes lysosomal accumulation of endogenous protein aggregates through ESCRT disruption.

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第一作者： John,Yong

第一单位： Calico Life Sciences LLC, South San Francisco, United States.

作者： John,Yong ^[1] ; Jacqueline E,Villalta ^[1] ; Ngoc,Vu ^[1] ; Matthew A,Kukurugya ^[1] ; Niclas,Olsson ^[1] ; Magdalena Preciado,López ^[1] ; Julia R,Lazzari-Dean ^[1] ; Kayley,Hake ^[1] ; Fiona E,McAllister ^[1] ; Bryson D,Bennett ^[1] ; Calvin H,Jan ^[1]

作者单位： Calico Life Sciences LLC, South San Francisco, United States. ^[1]

关键词 CRISPR ESCRT aggregation cell biology human lipid dysregulation lysosome proteostasis

主题词转运所需的胞内分选复合物(Endosomal Sorting Complexes Required for Transport);溶酶体(Lysosomes);人类(Humans);脂类代谢(Lipid Metabolism);内环境稳定(Homeostasis)

DOI 10.7554/eLife.86194

PMID 39713930

发布时间 2025-01-04

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