Deafness-associated mitochondrial 12S rRNA mutation reshapes mitochondrial and cellular homeostasis.

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作者： Yunfan,He ^[1] ; Zhining,Tang ^[2] ; Gao,Zhu ^[3] ; Luhang,Cai ^[4] ; Chao,Chen ^[4] ; Min-Xin,Guan ^[5]

作者单位： Center for Mitochondrial Biomedicine and Department of Otolaryngology-Head and Neck Surgery, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, Zhejiang, China; Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, Zhejiang, China; Center for Genetic Medicine, Zhejiang University International Institute of Medicine, Yiwu, Zhejiang, China. ^[1] Clinical Laboratory, Huzhou Central Hospital, Affiliated Central Hospital of Huzhou University, Huzhou, Zhejiang, China. ^[2] Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, Zhejiang, China. ^[3] Center for Mitochondrial Biomedicine and Department of Otolaryngology-Head and Neck Surgery, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, Zhejiang, China; Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, Zhejiang, China. ^[4] Center for Mitochondrial Biomedicine and Department of Otolaryngology-Head and Neck Surgery, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, Zhejiang, China; Institute of Genetics, Zhejiang University International School of Medicine, Hangzhou, Zhejiang, China; Center for Genetic Medicine, Zhejiang University International Institute of Medicine, Yiwu, Zhejiang, China; Joint Institute of Genetics and Genomic Medicine Between Zhejiang University and University of Toronto, Hangzhou, Zhejiang, China. Electronic address: gminxin88@zju.edu.cn. ^[5]

关键词 12S rRNA apoptotic pathways cellular Integrity deafness intracellular signaling mitochondrial DNA mutation mitophagy

DOI 10.1016/j.jbc.2024.108124

PMID 39716492

发布时间 2025-02-06

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