Comparative assessment of the transduction efficiency and safety associated with the delivery of AAV9-GFP vector via lumbar puncture to cynomolgus macaques with and without anti-AAV9 pre-existing antibodies.

导出 LinkOut

翻译打印收藏纠错

第一作者： Ghiabe H,Guibinga

第一单位： Novartis Gene Therapies, San Diego, CA, USA.;Biologics Research Center (BRC), Novartis Biomedical Research, San Diego, CA, USA.

作者： Ghiabe H,Guibinga ^[1] ; Janet,Do ^[2] ; Binh,Chu ^[2] ; Yin,Gu ^[1] ; Rie,Kikkawa ^[3] ; Xiaoguang,Li ^[4] ; Fatih,Ozsolak ^[1] ; Timothy,MacLachlan ^[5]

作者单位： Novartis Gene Therapies, San Diego, CA, USA.;Biologics Research Center (BRC), Novartis Biomedical Research, San Diego, CA, USA. ^[1] Novartis Gene Therapies, San Diego, CA, USA. ^[2] Preclinical Safety (PCS), Novartis Biomedical Research, East Hanover, NJ, USA. ^[3] Biologics Research Center (BRC), Novartis Biomedical Research, San Diego, CA, USA. ^[4] Preclinical Safety (PCS), Novartis Biomedical Research, Cambridge, MA, USA. ^[5]

关键词 AAV9 biomarkers intra-CSF dosing liver enzymes neutralizing antibody non-human primates pre-existing immunity toxicity transduction efficiency

DOI 10.1016/j.omtm.2024.101371

PMID 39717225

发布时间 2025-01-04

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交

浏览0

Molecular therapy. Methods & clinical development

2024年32卷4期

101371页

相似文献

中文期刊
外文期刊
学位论文
会议论文

检索历史清除

Comparative assessment of the transduction efficiency and safety associated with the delivery of AAV9-GFP vector via lumbar puncture to cynomolgus macaques with and without anti-AAV9 pre-existing antibodies.

Molecular therapy. Methods & clinical development

相似文献

Molecular therapy. Methods & clinical development

相关期刊

参考文献：
指定格式：	NoteExpress EndNote RefWorks NoteFirst

检索历史 清除

Comparative assessment of the transduction efficiency and safety associated with the delivery of AAV9-GFP vector via lumbar puncture to cynomolgus macaques with and without anti-AAV9 pre-existing antibodies.

Molecular therapy. Methods & clinical development

相似文献

Molecular therapy. Methods & clinical development

相关期刊

检索历史清除