Discovery of the first examples of right open reading frame kinase 2 (RIOK2) molecular glue degraders.

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第一作者： Haowen,Ma

第一单位： College of Chemistry and Materials Science, Zhejiang Normal University, No. 688 Yingbin Road, Jinhua, Zhejiang Province, 321004, China; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Discovery of Chinese Ministry of Education, College of Pharmacy, Jinan University, No. 601 Huangpu Avenue West, Guangzhou, 510530, China.

作者： Haowen,Ma ^[1] ; Cong,Liu ^[2] ; Zihao,Li ^[2] ; Qiuchun,Yu ^[2] ; Huilan,Xiong ^[2] ; Chaomin,Huang ^[3] ; Li,Tan ^[4] ; Min,Zhan ^[5] ; Zhang,Zhang ^[6] ; Qian,Cai ^[7]

作者单位： College of Chemistry and Materials Science, Zhejiang Normal University, No. 688 Yingbin Road, Jinhua, Zhejiang Province, 321004, China; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Discovery of Chinese Ministry of Education, College of Pharmacy, Jinan University, No. 601 Huangpu Avenue West, Guangzhou, 510530, China. ^[1] International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Discovery of Chinese Ministry of Education, College of Pharmacy, Jinan University, No. 601 Huangpu Avenue West, Guangzhou, 510530, China. ^[2] State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangzhou City Key Laboratory of Precision Chemical Drug Development, Guangzhou, 510630, China. ^[3] College of Chemistry and Materials Science, Zhejiang Normal University, No. 688 Yingbin Road, Jinhua, Zhejiang Province, 321004, China. Electronic address: tantanli@zjnu.edu.cn. ^[4] Department of Pharmacy, Shenzhen Children's Hospital, Shenzhen, 510038, China. Electronic address: zhanminhao@163.com. ^[5] International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Discovery of Chinese Ministry of Education, College of Pharmacy, Jinan University, No. 601 Huangpu Avenue West, Guangzhou, 510530, China; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangzhou City Key Laboratory of Precision Chemical Drug Development, Guangzhou, 510630, China. Electronic address: zhang_zhang@jnu.edu.cn. ^[6] College of Chemistry and Materials Science, Zhejiang Normal University, No. 688 Yingbin Road, Jinhua, Zhejiang Province, 321004, China; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Discovery of Chinese Ministry of Education, College of Pharmacy, Jinan University, No. 601 Huangpu Avenue West, Guangzhou, 510530, China. Electronic address: caiqian@zjnu.edu.cn. ^[7]

关键词 ATPase Degrader Kinase Molecular glue RIOK2

主题词人类(Humans);动物(Animals);细胞增殖(Cell Proliferation);抗肿瘤药(Antineoplastic Agents);小鼠(Mice);构效关系(Structure-Activity Relationship);细胞凋亡(Apoptosis);蛋白激酶抑制剂(Protein Kinase Inhibitors);分子结构(Molecular Structure);剂量效应关系, 药物(Dose-Response Relationship, Drug);药物发现(Drug Discovery);细胞系, 肿瘤(Cell Line, Tumor);药物筛选试验, 抗肿瘤(Drug Screening Assays, Antitumor);小鼠, 裸(Mice, Nude)

DOI 10.1016/j.ejmech.2024.117166

PMID 39721086

发布时间 2025-01-10

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European journal of medicinal chemistry

2025年283卷

117166页

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Discovery of the first examples of right open reading frame kinase 2 (RIOK2) molecular glue degraders.

European journal of medicinal chemistry

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European journal of medicinal chemistry

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Discovery of the first examples of right open reading frame kinase 2 (RIOK2) molecular glue degraders.

European journal of medicinal chemistry

相似文献

European journal of medicinal chemistry

相关期刊

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