Metformin-loaded nanoparticles reduce hyperglycemia-associated oxidative stress and induce eNOS phosphorylation in vascular endothelial cells.

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第一作者： Hana A,Mohamed

第一单位： Biomedical Research Center, Qatar University, PO Box 2713, Doha, Qatar.

作者： Hana A,Mohamed ^[1] ; Nura A,Mohamed ^[1] ; Shantelle S,Macasa ^[2] ; Hamda K,Basha ^[2] ; Adna M,Adan ^[2] ; Sergio,Crovella ^[3] ; Hong,Ding ^[4] ; Christopher R,Triggle ^[4] ; Isra,Marei ^[5] ; Haissam,Abou-Saleh ^[6]

作者单位： Biomedical Research Center, Qatar University, PO Box 2713, Doha, Qatar. ^[1] Biological and Environmental Sciences Department, Qatar University, PO Box 2713, Doha, Qatar. ^[2] Laboratory Animal Research Center, Qatar University, PO Box 2713, Doha, Qatar. ^[3] Department of Pharmacology, Weill Cornell Medicine in Qatar, P.O. Box 24144, Doha, Qatar. ^[4] Department of Pharmacology, Weill Cornell Medicine in Qatar, P.O. Box 24144, Doha, Qatar. isra.marei11@imperial.ac.uk.;Department of Cardiothoracic Pharmacology, National Heart and Lung Institute, Imperial College, London, SW7 2AZ, UK. isra.marei11@imperial.ac.uk. ^[5] Department of Biomedical Sciences, College of Health Sciences, Qatar University, PO Box 2713, Doha, Qatar. hasaleh@qu.edu.qa. ^[6]

关键词 Cardiovascular complications Diabetes mellitus Drug delivery Metformin NanoMIL-89 Nanomedicine