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首页> The Journal of steroid biochemistry and molecular biology> Segetalin B promotes bone formation in ovariectomized mice by activating PLD1/SIRT1 signaling to inhibit γ-secretase-mediated Notch1 overactivation.

Segetalin B promotes bone formation in ovariectomized mice by activating PLD1/SIRT1 signaling to inhibit γ-secretase-mediated Notch1 overactivation.

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作者： Huixian,Du ^[1] ; Furui,Tang ^[1] ; Haiping,Ma ^[2] ; Yipin,Xiong ^[3] ; Sijian,Lin ^[1] ; Zhen,Yuan ^[1] ; Jie,Wu ^[1] ; Binwu,Xu ^[1] ; Lei,Xiao ^[1] ; Xiaoyong,Lan ^[4]

作者单位： Department of Rehabilitation Medicine, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China. ^[1] Department of Nursing, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China. ^[2] Department of Ultrasound, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China. ^[3] Department of Rehabilitation Medicine, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China. Electronic address: lanxy_nc@126.com. ^[4]

关键词 Bone formation PLD1 Postmenopausal osteoporosis Segetalin B γ-Secretase

主题词动物(Animals);女(雌)性(Female);卵巢切除术(Ovariectomy);骨生成(Osteogenesis);磷脂酶D(Phospholipase D);抗衰老酶1(Sirtuin 1);小鼠(Mice);受体, Notch1(Receptor, Notch1);淀粉样前体蛋白分泌酶类(Amyloid Precursor Protein Secretases);信号传导(Signal Transduction);小鼠, 近交C57BL(Mice, Inbred C57BL);间质干细胞(Mesenchymal Stem Cells);骨质疏松(Osteoporosis);细胞, 培养的(Cells, Cultured);细胞分化(Cell Differentiation);人类(Humans)

DOI 10.1016/j.jsbmb.2024.106669

PMID 39736459

发布时间 2025-02-09

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The Journal of steroid biochemistry and molecular biology

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