Early changes of peripheral circulating immune subsets induced by PD-1 inhibitors in patients with advanced malignant melanoma and non-small cell lung cancer.

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作者： Simona,Borilova ^[1] ; Peter,Grell ^[2] ; Iveta,Selingerova ^[3] ; Lenka,Gescheidtova ^[3] ; Marie,Mlnarikova ^[4] ; Ondrej,Bilek ^[1] ; Radek,Lakomy ^[1] ; Alexandr,Poprach ^[1] ; Jan,Podhorec ^[1] ; Igor,Kiss ^[1] ; Rostislav,Vyzula ^[1] ; Barbora,Vavrusakova ^[5] ; Jiri,Nevrlka ^[6] ; Lenka,Zdrazilova-Dubska ^[6]

作者单位： Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Brno, Czech Republic.;Department of Comprehensive Cancer Care, Faculty of Medicine, Masaryk University, Brno, Czech Republic. ^[1] Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Brno, Czech Republic. peter.grell@mou.cz.;Department of Comprehensive Cancer Care, Faculty of Medicine, Masaryk University, Brno, Czech Republic. peter.grell@mou.cz. ^[2] Department of Laboratory Medicine, Masaryk Memorial Cancer Institute, Brno, Czech Republic.;Department of Pharmacology, Faculty of Medicine, Masaryk University, Brno, Czech Republic. ^[3] Department of Pharmacology, Faculty of Medicine, Masaryk University, Brno, Czech Republic. ^[4] Research Center for Applied Molecular Oncology (RECAMO), Masaryk Memorial Cancer Institute, Brno, Czech Republic.;Faculty of Medicine, Masaryk University, Brno, Czech Republic. ^[5] Department of Pharmacology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.;Department of Laboratory Medicine, Department of Laboratory Methods, Faculty of Medicine and University Hospital Brno, Masaryk University, Brno, Czech Republic. ^[6]

关键词 Antitumor immunity Immune checkpoint inhibitors Peripheral blood circulating immune subsets Predictive biomarker