nsP2 Protease Inhibitor Blocks the Replication of New World Alphaviruses and Offer Protection in Mice.

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第一作者： Olawale S,Adeyinka

第一单位： Chemistry and Biotechnology Science and Engineering Program, College of Science, The University of Alabama in Huntsville, Huntsville, Alabama 35899, United States.

作者： Olawale S,Adeyinka ^[1] ; Michael D,Barrera ^[2] ; Damilohun S,Metibemu ^[1] ; Niloufar,Boghdeh ^[3] ; Carol A,Anderson ^[2] ; Haseebullah,Baha ^[4] ; Olamide,Crown ^[1] ; John Adeolu,Falode ^[1] ; Janard L,Bleach ^[3] ; Amanda R,Bliss ^[3] ; Tamia P,Hampton ^[1] ; Jane-Frances Chinenye,Ojobor ^[1] ; Farhang,Alem ^[5] ; Aarthi,Narayanan ^[6] ; Ifedayo Victor,Ogungbe ^[1]

作者单位： Chemistry and Biotechnology Science and Engineering Program, College of Science, The University of Alabama in Huntsville, Huntsville, Alabama 35899, United States. ^[1] Department of Biology, College of Science, George Mason University, Fairfax, Virginia 22030, United States.;School of Systems Biology, College of Science, George Mason University, Fairfax, Virginia 22030, United States. ^[2] School of Systems Biology, College of Science, George Mason University, Fairfax, Virginia 22030, United States.;Biomedical Research Laboratory, Institute for Biohealth Innovation, George Mason University, Manassas, Virginia 20109, United States. ^[3] School of Systems Biology, College of Science, George Mason University, Fairfax, Virginia 22030, United States. ^[4] Biomedical Research Laboratory, Institute for Biohealth Innovation, George Mason University, Manassas, Virginia 20109, United States. ^[5] Department of Biology, College of Science, George Mason University, Fairfax, Virginia 22030, United States. ^[6]

关键词 VEEV alphaviruses covalent inhibitors nonstructural protein nsP2 protease vinyl sulfone

主题词动物(Animals);小鼠(Mice);病毒复制(Virus Replication);抗病毒药(Antiviral Agents);甲病毒属(Alphavirus);蛋白酶抑制药(Protease Inhibitors);甲病毒感染(Alphavirus Infections);半胱氨酸内肽酶类(Cysteine Endopeptidases);脑炎病毒, 委内瑞拉马(Encephalitis Virus, Venezuelan Equine);人类(Humans);女(雌)性(Female);疾病模型, 动物(Disease Models, Animal)

DOI 10.1021/acsinfecdis.4c00701

PMID 39737550

发布时间 2025-01-10

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ACS infectious diseases

2025年11卷1期

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nsP2 Protease Inhibitor Blocks the Replication of New World Alphaviruses and Offer Protection in Mice.

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nsP2 Protease Inhibitor Blocks the Replication of New World Alphaviruses and Offer Protection in Mice.

ACS infectious diseases

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