A nucleoside-modified rabies mRNA vaccine induces long-lasting and comprehensive immune responses in mice and non-human primates.

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第一作者： Yu,Wang

第一单位： School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211112, China; Xuzhou Medical University, Xuzhou 221004, China.

作者： Yu,Wang ^[1] ; Shen,Wang ^[2] ; Lulu,Huang ^[3] ; Wenhao,Mao ^[3] ; Fangmeng,Li ^[3] ; Ang,Lin ^[4] ; Weijun,Zhao ^[5] ; Xianhuan,Zeng ^[6] ; Yue,Zhang ^[3] ; Dingcao,Yang ^[3] ; Yuhong,Han ^[6] ; Yidan,Li ^[3] ; Leyuan,Ren ^[3] ; Ying,Li ^[7] ; Liang,Zhang ^[8] ; Feihu,Yan ^[9] ; Yong,Yang ^[10] ; Xinying,Tang ^[11]

作者单位： School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211112, China; Xuzhou Medical University, Xuzhou 221004, China. ^[1] Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130000, China. ^[2] School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211112, China. ^[3] School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211112, China; Institute of Translational Medicine, China Pharmaceutical University, Nanjing 211112, China. ^[4] Institute of Translational Medicine, China Pharmaceutical University, Nanjing 211112, China; Center for New Drug Safety Evaluation and Research, China Pharmaceutical University, Nanjing 211112, China. ^[5] Center for New Drug Safety Evaluation and Research, China Pharmaceutical University, Nanjing 211112, China. ^[6] Translational Medicine Research Institute, Yangzhou University, Yangzhou 225001, China. ^[7] School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211112, China; Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou 310022, China. Electronic address: liangzhang.cs@hotmail.com. ^[8] Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130000, China. Electronic address: yanfh1990@163.com. ^[9] School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211112, China; Institute of Translational Medicine, China Pharmaceutical University, Nanjing 211112, China; Center for New Drug Safety Evaluation and Research, China Pharmaceutical University, Nanjing 211112, China; Xuzhou Medical University, Xuzhou 221004, China. Electronic address: yy@cpu.edu.cn. ^[10] School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211112, China; Institute of Translational Medicine, China Pharmaceutical University, Nanjing 211112, China. Electronic address: xinyingtang@cpu.edu.cn. ^[11]

关键词 cell-mediated immunity germinal center humoral immunity inactivated vaccine long-lasting antibody mRNA vaccine non-human primate rabies