Development and optimization of dapagliflozin oral nano-bilosomes using response surface method: <i>in vitro</i> evaluation, <i>in vivo</i> evaluation.

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第一作者： Ananda Kumar,Chettupalli

第一单位： Department of Pharmaceutical Siences, School of Pharmacy, Galgotias University, Greater Noida, Uttar Pradesh 203201, India.

作者： Ananda Kumar,Chettupalli ^[1] ; Nihar Ranjan,Kar ^[2] ; V T,Iswariya ^[3] ; Uttam Prasad,Panigrahy ^[4] ; Laliteshwar Pratap,Singh ^[5] ; Harekrishna,Roy ^[6] ; Deepadarshan,Urs ^[7] ; Muralidharan,V ^[8] ; Sandhya Rani,Mandadi ^[8] ; M Akiful,Haque ^[1] ; Ritesh,Rana ^[9] ; Talha Bin,Emran ^[10]

作者单位： Department of Pharmaceutical Siences, School of Pharmacy, Galgotias University, Greater Noida, Uttar Pradesh 203201, India. ^[1] Centurion University of Technology and Management, Odisha, India. ^[2] CMR College of Pharmacy, Kandlakoya, Medchal, Telangana, India. ^[3] Faculty of Pharmaceutical Science, Assam Down Town University, Sankar Madhab Path, Gandhi Nagar, Panikhaiti, Guwahati, Assam, 781026, India. ^[4] Narayan Institute of Pharmacy, Gopal Narayan Singh University, Sasaram, Bihar, India. ^[5] Department of Pharmaceutics, Nirmala College of Pharmacy, Mangalagiri, Guntur, Andhra Pradesh, India. ^[6] Inflammation Research Laboratory, Department of Studies and Research in Biochemistry, Mangalore University, Karnataka, India. ^[7] Vishnu Institute of Pharmaceutical Education and Research, Narsapur, Telangana, India. ^[8] Himachal Institute of Pharmaceutical Education and Research, Nadaun, Himachal Pradesh, India. ^[9] Department of Pathology and Laboratory Medicine, Warren Alpert Medical School, Brown University, Providence, RI 02912, USA.;Legorreta Cancer Center, Brown University, Providence, RI 02912, USA.;Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka 1207, Bangladesh. ^[10]

关键词 Dapagliflozin Edge activator Nano Bilosomes Permeation study glucotoxicity hyperglycemia

主题词动物(Animals);二苯甲基化合物(Benzhydryl Compounds);葡糖苷类(Glucosides);投药, 口服(Administration, Oral);大鼠(Rats);粒子大小(Particle Size);脂质体(Liposomes);男(雄)性(Male);大鼠, Wistar(Rats, Wistar);纳米粒子(Nanoparticles);降血糖药(Hypoglycemic Agents);皮肤吸收(Skin Absorption);糖尿病, 2型(Diabetes Mellitus, Type 2)

DOI 10.7150/ntno.99271

PMID 39744098

发布时间 2025-01-04

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2025年9卷1期

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Development and optimization of dapagliflozin oral nano-bilosomes using response surface method: <i>in vitro</i> evaluation, <i>in vivo</i> evaluation.

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Development and optimization of dapagliflozin oral nano-bilosomes using response surface method: <i>in vitro</i> evaluation, <i>in vivo</i> evaluation.

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