首页> Virologica Sinica> Random forest algorithm reveals novel sites in HA protein that shift receptor binding preference of the H9N2 avian influenza virus.

Random forest algorithm reveals novel sites in HA protein that shift receptor binding preference of the H9N2 avian influenza virus.

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第一作者： Yuncong,Yin

第一单位： College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China; Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Disease and Zoonoses, Yangzhou University, Yangzhou 225009, China; International Joint Laboratory for Cooperation in Agriculture and Agricultural Product Safety, Ministry of Education, Yangzhou University, Yangzhou 225009, China.

作者： Yuncong,Yin ^[1] ; Wen,Li ^[2] ; Rujian,Chen ^[2] ; Xiao,Wang ^[2] ; Yiting,Chen ^[2] ; Xinyuan,Cui ^[2] ; Xingbang,Lu ^[2] ; David M,Irwin ^[3] ; Xuejuan,Shen ^[2] ; Yongyi,Shen ^[4]

作者单位： College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China; Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Disease and Zoonoses, Yangzhou University, Yangzhou 225009, China; International Joint Laboratory for Cooperation in Agriculture and Agricultural Product Safety, Ministry of Education, Yangzhou University, Yangzhou 225009, China. ^[1] Guangdong Laboratory for Lingnan Modern Agriculture, State Key Laboratory for Animal Disease Control and Prevention, Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China. ^[2] Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto M5S1A8, Canada; Banting and Best Diabetes Centre, University of Toronto, Toronto M5S1A8, Canada. ^[3] Guangdong Laboratory for Lingnan Modern Agriculture, State Key Laboratory for Animal Disease Control and Prevention, Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China; School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China; Guangdong Provincial Key Laboratory of Zoonosis Prevention and Control, Guangzhou 510642, China. Electronic address: shenyy@scau.edu.cn. ^[4]

关键词 H9N2 Hemagglutinin (HA)Host shift Interspecies transmission Random forest algorithm Receptor binding preference