SiCLAT: simultaneous imaging of chromatin loops and active transcription in living cells.

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作者： Xin,Wan ^[1] ; Jie,Kong ^[2] ; Xiaodi,Hu ^[2] ; Lulu,Liu ^[3] ; Yuanping,Yang ^[4] ; Hu,Li ^[4] ; Gaoao,Liu ^[2] ; Xingchen,Niu ^[5] ; Fengling,Chen ^[6] ; Dan,Zhang ^[5] ; Dahai,Zhu ^[7] ; Yong,Zhang ^[8]

作者单位： State Key Laboratory for Complex, Severe, and Rare Diseases, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, China. xinwan@ibms.pumc.edu.cn. ^[1] State Key Laboratory for Complex, Severe, and Rare Diseases, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, China. ^[2] Center for Biomedical Technology of National Infrastructures for Translational Medicine, State Key Laboratory of Complex, Severe, and Rare Diseases in Peking Union Medical College Hospital, Beijing, China. ^[3] Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, China. ^[4] Experimental Center, Shandong University of Traditional Chinese Medicine, Jinan, China.;Key Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Jinan, China. ^[5] Center for Stem Cell Biology and Regenerative Medicine, MOE Key Laboratory of Bioinformatics, New Cornerstone Science Laboratory, School of Life Sciences, Tsinghua University, Beijing, China. ^[6] State Key Laboratory for Complex, Severe, and Rare Diseases, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, China. dhzhu@pumc.edu.cn.;Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, China. dhzhu@pumc.edu.cn. ^[7] State Key Laboratory for Complex, Severe, and Rare Diseases, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, China. yongzhang@ibms.pumc.edu.cn. ^[8]

关键词 3D genome CRISPR imaging Enhancer and promoter interaction Genetic mouse model Living primary cell Non-repetitive DNA and RNA imaging

主题词动物(Animals);染色质(Chromatin);小鼠(Mice);转录, 遗传(Transcription, Genetic);增强子元件, 遗传学(Enhancer Elements, Genetic);启动区, 遗传(Promoter Regions, Genetic);细胞分化(Cell Differentiation)

DOI 10.1186/s13059-024-03463-9

PMID 39748374

发布时间 2025-01-05

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