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Context-dependent effects of CDKN2A and other 9p21 gene losses during the evolution of esophageal cancer.

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第一作者： Piyali,Ganguli

第一单位： Cancer Systems Biology Laboratory, The Francis Crick Institute, London, UK.;Barts Cancer Institute - Centre for Cancer Evolution, Queen Mary University of London, London, UK.

作者： Piyali,Ganguli ^[1] ; Celia C,Basanta ^[1] ; Amelia,Acha-Sagredo ^[1] ; Hrvoje,Misetic ^[1] ; Maria,Armero ^[1] ; Akram,Mendez ^[1] ; Aeman,Zahra ^[1] ; Ginny,Devonshire ^[2] ; Gavin,Kelly ^[3] ; Adam,Freeman ^[2] ; Mary,Green ^[4] ; Emma,Nye ^[4] ; Anita,Bichisecchi ^[5] ; Paola,Bonfanti ^[5] ; Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium ^[6] ; Manuel,Rodriguez-Justo ^[7] ; Jo,Spencer ^[2] ; Rebecca C,Fitzgerald ^[8] ; Francesca D,Ciccarelli

作者单位： Cancer Systems Biology Laboratory, The Francis Crick Institute, London, UK.;Barts Cancer Institute - Centre for Cancer Evolution, Queen Mary University of London, London, UK. ^[1] Early Cancer Institute, Hutchison Research Centre, University of Cambridge, Cambridge, UK. ^[2] Bioinformatics & Biostatistics STP, The Francis Crick Institute, London, UK. ^[3] Experimental Histopathology STP, The Francis Crick Institute, London, UK. ^[4] Epithelial Stem Cell Biology & Regenerative Medicine Laboratory, The Francis Crick Institute, London, UK.;Institute of Immunity & Transplantation, Division of Infection & Immunity, UCL, London, UK. ^[5] Department of Pathology, UCL Cancer Institute, London, UK. ^[6] School of Immunology and Microbial Sciences, King's College London, London, UK. ^[7] Cancer Systems Biology Laboratory, The Francis Crick Institute, London, UK. f.ciccarelli@qmul.ac.uk.;Barts Cancer Institute - Centre for Cancer Evolution, Queen Mary University of London, London, UK. f.ciccarelli@qmul.ac.uk. ^[8]

医学主题词人类(Humans);食管肿瘤(Esophageal Neoplasms);周期素依赖激酶抑制剂p16(Cyclin-Dependent Kinase Inhibitor p16);染色体, 人, 9对(Chromosomes, Human, Pair 9);腺癌(Adenocarcinoma);Barrett食管(Barrett Esophagus);基因缺失(Gene Deletion);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);男(雄)性(Male);女(雌)性(Female);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53)

DOI 10.1038/s43018-024-00876-0

PMID 39753721

发布时间 2025-05-30

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Context-dependent effects of CDKN2A and other 9p21 gene losses during the evolution of esophageal cancer.

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Context-dependent effects of CDKN2A and other 9p21 gene losses during the evolution of esophageal cancer.

Nature cancer

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Nature cancer

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