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ZIC1 is a context-dependent medulloblastoma driver in the rhombic lip.

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作者: John J Y,Lee [1] ; Ran,Tao [2] ; Zhen,You [3] ; Parthiv,Haldipur [4] ; Anders W,Erickson [5] ; Hamza,Farooq [5] ; Liam D,Hendriske [6] ; Namal,Abeysundara [7] ; Cory M,Richman [8] ; Evan Y,Wang [8] ; Neha,Das Gupta [2] ; Jennifer,Hadley [2] ; Melissa,Batts [2] ; Christopher W,Mount [9] ; Xiaochong,Wu [10] ; Alex,Rasnitsyn [8] ; Swneke,Bailey [7] ; Florence M G,Cavalli [11] ; Sorana,Morrissy [12] ; Livia,Garzia [13] ; Kulandaimanuvel Antony,Michealraj [7] ; Abhi,Visvanathan [7] ; Vernon,Fong [5] ; Jonelle,Palotta [7] ; Raul,Suarez [7] ; Bryn G,Livingston [5] ; Miao,Liu [14] ; Betty,Luu [7] ; Craig,Daniels [10] ; James,Loukides [7] ; Anne,Bendel [15] ; Pim J,French [16] ; Johan M,Kros [17] ; Andrey,Korshunov [18] ; Marcel,Kool [19] ; Fernando,Chico Ponce de León [20] ; Mario,Perezpeña-Diazconti [21] ; Boleslaw,Lach [22] ; Sheila K,Singh [23] ; Sarah E S,Leary [24] ; Byung-Kyu,Cho [25] ; Seung-Ki,Kim [25] ; Kyu-Chang,Wang [26] ; Ji-Yeoun,Lee [25] ; Teiji,Tominaga [27] ; William A,Weiss [28] ; Joanna J,Phillips [28] ; Shizhong,Dai [29] ; Gelareh,Zadeh [30] ; Ali G,Saad [31] ; László,Bognár [32] ; Almos,Klekner [32] ; Ian F,Pollack [33] ; Ronald L,Hamilton [34] ; Young-Shin,Ra [35] ; Wieslawa A,Grajkowska [36] ; Marta,Perek-Polnik [37] ; Reid C,Thompson [38] ; Anna M,Kenney [39] ; Michael K,Cooper [40] ; Stephen C,Mack [41] ; Nada,Jabado [42] ; Mathieu,Lupien [43] ; Marco,Gallo [44] ; Vijay,Ramaswamy [7] ; Mario L,Suva [9] ; Hiromichi,Suzuki [45] ; Kathleen J,Millen [46] ; L Frank,Huang [47] ; Paul A,Northcott [48] ; Michael D,Taylor [49]
作者单位: Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.;The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, Ontario, Canada.;Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.;Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.;Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, MA, USA. [1] Center of Excellence in Neuro-Oncology Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.;Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA. [2] Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA. [3] Norcliffe Foundation Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA. [4] Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.;The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, Ontario, Canada.;Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada. [5] Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.;The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, Ontario, Canada.;Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.;Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. [6] The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, Ontario, Canada.;Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada. [7] The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, Ontario, Canada.;Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.;Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. [8] Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.;Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, MA, USA. [9] The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, Ontario, Canada.;Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.;Texas Children's Cancer and Hematology Center, Houston, TX, USA.;Department of Pediatrics-Hematology/Oncology, Baylor College of Medicine, Houston, TX, USA. [10] Inserm, Paris, France.;Institut Curie, PSL Research University, Paris, France.;MINES ParisTech, CBIO-Centre for Computational Biology, PSL Research University, Paris, France. [11] The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, Ontario, Canada.;Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.;Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada. [12] Department of Surgery, McGill University and RI-MUHC Cancer Research Program, Montreal, Quebec, Canada. [13] Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, USA. [14] Department of Pediatric Hematology-Oncology, Children's Hospital of Minnesota, Minneapolis, MN, USA. [15] Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands. [16] Department of Pathology, Erasmus University Medical Center, Rotterdam, The Netherlands. [17] Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany. [18] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Research Consortium (DKTK), Heidelberg, Germany.;Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.;Princess Maxima Center for Pediatric Oncology, Utrecht, the Netherlands.;Utrecht University Medical Center (UMCU), Utrecht, the Netherlands. [19] Department of Neurosurgery, Hospital Infantil de Mexico Federico Gomez, Mexico City, Mexico. [20] Department of Pathology, Instituto Nacional de Pediatria, Mexico City, Mexico. [21] Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada. [22] Department of Surgery, McMaster University, Hamilton, Ontario, Canada. [23] Cancer and Blood Disorders Center, Seattle Children's Hospital, Seattle, WA, USA. [24] Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, Seoul, Republic of Korea. [25] Neuro-Oncology Clinic, National Cancer Center, Goyang, Republic of Korea. [26] Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan. [27] Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA. [28] Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, USA. [29] Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. [30] Department of Pediatric Pathology and Neuropathology, University of Miami Miller School of Medicine, Miami, FL, USA. [31] Department of Neurosurgery, University of Debrecen, Debrecen, Hungary. [32] Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. [33] Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. [34] Department of Neurosurgery, University of Ulsan Asan Medical Center, Ulsan, Republic of Korea. [35] Department of Pathology, The Children's Memorial Health Institute, Warsaw, Poland. [36] Department of Oncology, The Children's Memorial Health Institute, Warsaw, Poland. [37] Department of Neurological Surgery, Vanderbilt Medical Center, Nashville, TN, USA. [38] Department of Pediatrics, Emory University, Atlanta, GA, USA. [39] Department of Neurology, Vanderbilt Medical Center, Nashville, TN, USA. [40] Center of Excellence in Neuro-Oncology Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA. [41] Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada.;Department of Human Genetics, McGill University, Montreal, Quebec, Canada. [42] Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.;Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. [43] Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.;Cancer and Hematology Center, Texas Children's Hospital, Houston, TX, USA.;Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA. [44] Division of Brain Tumor Translational Research, National Cancer Center Research Institute, Tokyo, Japan. [45] Norcliffe Foundation Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA.;Department of Pediatrics, University of Washington, Seattle, WA, USA. [46] Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA. huang.frank@mayo.edu.;Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, USA. huang.frank@mayo.edu. [47] Center of Excellence in Neuro-Oncology Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA. paul.northcott@stjude.org.;Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA. paul.northcott@stjude.org. [48] Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. mdt.cns@gmail.com.;The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, Ontario, Canada. mdt.cns@gmail.com.;Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada. mdt.cns@gmail.com.;Norcliffe Foundation Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA. mdt.cns@gmail.com.;Texas Children's Cancer and Hematology Center, Houston, TX, USA. mdt.cns@gmail.com.;Department of Pediatrics-Hematology/Oncology, Baylor College of Medicine, Houston, TX, USA. mdt.cns@gmail.com.;Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA. mdt.cns@gmail.com.;Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USA. mdt.cns@gmail.com.;Department of Neurosurgery, Texas Children's Hospital, Houston, TX, USA. mdt.cns@gmail.com. [49]
DOI 10.1038/s41588-024-02014-z
PMID 39753768
发布时间 2025-01-03
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