Harnessing acylhydrazone-oxime exchange reaction to achieve diverse synthesis of glycosite-specific antibody-drug conjugates.

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作者： Fei,Xia ^[1] ; Zhi,Liu ^[2] ; Jiaying,Hang ^[3] ; Hao,Xu ^[4] ; Yuting,Xiao ^[5] ; Shuyue,Niu ^[5] ; Ji,Qin ^[6] ; Songyue,Lou ^[6] ; Bo,Liu ^[7] ; Feng,Tang ^[7] ; Wei,Huang ^[8] ; Yang,Yang ^[9] ; Wei,Shi ^[9]

作者单位： Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing, 100005, China.;State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, No. 555 Zuchongzhi Rd, Pudong, Shanghai 201203, China.;University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China. ^[1] State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, No. 555 Zuchongzhi Rd, Pudong, Shanghai 201203, China.;Lingang Laboratory, Shanghai, 200031, China.;School of Physical Science and Technology, ShanghaiTech University, Shanghai, 201210, China. ^[2] State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, No. 555 Zuchongzhi Rd, Pudong, Shanghai 201203, China.;University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China. ^[3] School of Chinese Materia Medica, Nanjing University of Chinese Medicine, No. 138 Xianlin Rd, Nanjing 210023, China. ^[4] School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China. ^[5] School of Pharmaceutical Science and Technology, Hangzhou Institute of Advanced Study, Hangzhou 310024, China. hsw201204@163.com.;University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China. ^[6] School of Pharmaceutical Science and Technology, Hangzhou Institute of Advanced Study, Hangzhou 310024, China. hsw201204@163.com.;State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, No. 555 Zuchongzhi Rd, Pudong, Shanghai 201203, China. ^[7] School of Pharmaceutical Science and Technology, Hangzhou Institute of Advanced Study, Hangzhou 310024, China. hsw201204@163.com.;State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, No. 555 Zuchongzhi Rd, Pudong, Shanghai 201203, China.;University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China.;Shanghai GlycanLink Biotech. Co. Ltd, Zhangjiang, Shanghai 201210, China. ^[8] School of Pharmaceutical Science and Technology, Hangzhou Institute of Advanced Study, Hangzhou 310024, China. hsw201204@163.com.;State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, No. 555 Zuchongzhi Rd, Pudong, Shanghai 201203, China.;University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China. ^[9]