Helicobacter pylori infection promotes M1 macrophage polarization and gastric inflammation by activation of NLRP3 inflammasome via TNF/TNFR1 axis.

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作者： Xiao,Fei ^[1] ; Sihai,Chen ^[2] ; Leyan,Li ^[1] ; Xinbo,Xu ^[1] ; Huan,Wang ^[2] ; Huajing,Ke ^[1] ; Cong,He ^[1] ; Chuan,Xie ^[1] ; Xidong,Wu ^[3] ; Jianping,Liu ^[1] ; Yong,Xie ^[1] ; Nonghua,Lu ^[1] ; Yin,Zhu ^[4] ; Nianshuang,Li ^[5]

作者单位： Department of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China. ^[1] Department of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.;Postdoctoral Innovation Practice Base, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China. ^[2] Department of Drug Safety Evaluation, Jiangxi Testing Center of Medical Instruments, Nanchang, China. ^[3] Department of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China. ndyfy01977@ncu.edu.cn. ^[4] Department of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China. ndyfy05390@ncu.edu.cn. ^[5]

关键词 H. pylori Gastritis Macrophage NLRP3 inflammasome TNF/TNFR1 axis