NEK2 Phosphorylates RhoGDI1 to Promote Cell Proliferation, Migration and Invasion Through the Activation of RhoA and Rac1 in Colon Cancer Cells.

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作者： Jeewon,Lim ^[1] ; Yo-Sep,Hwang ^[2] ; Jong-Tae,Kim ^[2] ; Hyang-Ran,Yoon ^[2] ; Hyo-Min,Park ^[2] ; Jahyeong,Han ^[1] ; Taeho,Kwon ^[3] ; Kyung-Ho,Lee ^[4] ; Hee-Jun,Cho ^[1] ; Hee-Gu,Lee ^[1]

作者单位： Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.;Department of Biomolecular Science, University of Science and Technology (UST), Daejeon 34113, Republic of Korea. ^[1] Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea. ^[2] Primate Resources Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup 56216, Republic of Korea. ^[3] Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28644, Republic of Korea. ^[4]

关键词 NEK2 Rho GTPase RhoGDI1 cancer migration proliferation

主题词人类(Humans);细胞增殖(Cell Proliferation);细胞运动(Cell Movement);磷酰化(Phosphorylation);ρA GTP结合蛋白质(rhoA GTP-Binding Protein);rac1 GTP结合蛋白质(rac1 GTP-Binding Protein);动物(Animals);结肠肿瘤(Colonic Neoplasms);细胞系, 肿瘤(Cell Line, Tumor);肿瘤侵润(Neoplasm Invasiveness);小鼠(Mice);小鼠, 裸(Mice, Nude);蛋白质结合(Protein Binding)

DOI 10.3390/cells13242072

PMID 39768163

发布时间 2025-01-08

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2024年13卷24期

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NEK2 Phosphorylates RhoGDI1 to Promote Cell Proliferation, Migration and Invasion Through the Activation of RhoA and Rac1 in Colon Cancer Cells.

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NEK2 Phosphorylates RhoGDI1 to Promote Cell Proliferation, Migration and Invasion Through the Activation of RhoA and Rac1 in Colon Cancer Cells.

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