首页> Pharmaceutics> Early-Stage IM Treatment with the Host-Derived Immunostimulant CPDI-02 Increases Curative Protection of Healthy Outbred Mice Against Subcutaneous Infection with Community-Acquired Methicillin-Resistant <i>Staphylococcus aureus</i> USA300.

Early-Stage IM Treatment with the Host-Derived Immunostimulant CPDI-02 Increases Curative Protection of Healthy Outbred Mice Against Subcutaneous Infection with Community-Acquired Methicillin-Resistant <i>Staphylococcus aureus</i> USA300.

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第一作者： Jason P,Stewart

第一单位： Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68198, USA.

作者： Jason P,Stewart ^[1] ; Caleb M,Sandall ^[1] ; Jacob E,Parriott ^[1] ; Stephen M,Curran ^[1] ; Russell J,McCulloh ^[2] ; Donald R,Ronning ^[1] ; Joy A,Phillips ^[3] ; Robin,Schroeder ^[4] ; Christy,Neel ^[4] ; Kelly F,Lechtenberg ^[4] ; Samuel M,Cohen ^[5] ; Yazen,Alnouti ^[1] ; Sohel,Daria ^[1] ; D David,Smith ^[6] ; Joseph A,Vetro ^[7]

作者单位： Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68198, USA. ^[1] Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE 68198, USA. ^[2] Biology Department, San Diego State University, San Diego, CA 92182, USA. ^[3] Midwest Veterinary Services, Inc., Oakland, NE 68045, USA. ^[4] Department of Pathology, Microbiology, and Immunology and the Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA. ^[5] Department of Biomedical Sciences, Creighton University, Omaha, NE 68178, USA. ^[6] Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68198, USA.;Center for Drug Delivery and Nanomedicine, University of Nebraska Medical Center, Omaha, NE 68198, USA. ^[7]

关键词 ABR AMR CPDI-02 dosing CPDI-02 toxicity EP67 MDR administration route antibiotic resistance antibiotic-resistant bacteria antimicrobial resistance complement peptide-derived immunostimulant drug-resistant bacteria host-directed therapy multidrug resistance

DOI 10.3390/pharmaceutics16121621

PMID 39771599

发布时间 2026-04-10

基金项目

5R01AI125137/NIH/NIAID 1R01AI121050/NIH/NIAID n/a/Weitz Family Foundation UG1OD024953/NIH Office of the Director GM103427/NIH/NIGMS GM139762/NIH/NIGMS

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