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Regulation of fibronectin and collagens type I, III and VI by TNF-α, TGF-β, IL-13, and tofacitinib.

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第一作者： Frederik S,Gillesberg

第一单位： Nordic Bioscience, Immunoscience, Herlev Hovedgade 205-207, Herlev, 2730, Denmark. frg@nordicbio.com.;Department of Biomedicine, Aarhus University, Høegh-Guldbergs Gade 10, Aarhus C, 8000, Denmark. frg@nordicbio.com.

作者： Frederik S,Gillesberg ^[1] ; Martin,Pehrsson ^[2] ; Anne-Christine,Bay-Jensen ^[2] ; Peder,Frederiksen ^[2] ; Morten,Karsdal ^[2] ; Bent W,Deleuran ^[3] ; Tue W,Kragstrup ^[4] ; Satoshi,Kubo ^[5] ; Yoshiya,Tanaka ^[5] ; Joachim H,Mortensen ^[2]

作者单位： Nordic Bioscience, Immunoscience, Herlev Hovedgade 205-207, Herlev, 2730, Denmark. frg@nordicbio.com.;Department of Biomedicine, Aarhus University, Høegh-Guldbergs Gade 10, Aarhus C, 8000, Denmark. frg@nordicbio.com. ^[1] Nordic Bioscience, Immunoscience, Herlev Hovedgade 205-207, Herlev, 2730, Denmark. ^[2] Department of Biomedicine, Aarhus University, Høegh-Guldbergs Gade 10, Aarhus C, 8000, Denmark.;Department of Rheumatology, Århus University Hospital, Palle Juul-Jensens Boulevard 99, Aarhus N, 8200, Denmark. ^[3] Department of Biomedicine, Aarhus University, Høegh-Guldbergs Gade 10, Aarhus C, 8000, Denmark.;Department of Rheumatology, Århus University Hospital, Palle Juul-Jensens Boulevard 99, Aarhus N, 8200, Denmark.;Diagnostic Center, Regional Hospital Silkeborg, Falkevej 1, Silkeborg, 8600, Denmark. ^[4] The First Department of Internal Medicine, School of Medicine, University of Occupational & Environmental Health, Japan, 1-1 Iseigaoka, Yahata-nishi, 807-8555, Kitakyushu, Japan. ^[5]

关键词 Collagen Fibro-inflammation Fibrosis JAK inhibitor Tofacitinib Wound healing

医学主题词嘧啶类(Pyrimidines);人类(Humans);哌啶类(Piperidines);白细胞介素13(Interleukin-13);肿瘤坏死因子α(Tumor Necrosis Factor-alpha);纤连蛋白类(Fibronectins);成纤维细胞(Fibroblasts);胶原Ⅰ型(Collagen Type I);关节炎, 类风湿(Arthritis, Rheumatoid);转化生长因子β(Transforming Growth Factor beta);胶原Ⅲ型(Collagen Type III);纤维化(Fibrosis);女(雌)性(Female);转化生长因子β1(Transforming Growth Factor beta1);男(雄)性(Male);细胞, 培养的(Cells, Cultured);中年人(Middle Aged);吡咯类(Pyrroles)

DOI 10.1038/s41598-024-84151-3

PMID 39774197

发布时间 2025-03-31

基金项目

1044-00131B/Innovation Fund Denmark 1044-00131B/Innovation Fund Denmark 1044-00131B/Innovation Fund Denmark 1044-00131B/Innovation Fund Denmark 1044-00131B/Innovation Fund Denmark

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