Design, synthesis, and biological evaluation of N<sup>1</sup>-(2-(adamantan-1-yl)-1H-indol-5-yl)-N<sup>2</sup>-(substituent)-1,2-dicarboxamides as anticancer agents targeting Nur77-mediated endoplasmic reticulum stress.

导出 LinkOut

翻译打印收藏纠错

作者： Hongyu,Hu ^[1] ; Fangfang,Wen ^[2] ; Tidong,Zhen ^[3] ; Minda,Zhang ^[3] ; Jingbo,Qin ^[3] ; Jiangang,Huang ^[1] ; Zhirong,Chen ^[4] ; Mingyue,Yu ^[5] ; Shengwei,Hu ^[3] ; Meijuan,Fang ^[6] ; Jin-Zhang,Zeng ^[7]

作者单位： Xingzhi College, Zhejiang Normal University, Lanxi 321004, China. ^[1] State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen 361102, China; Community Health Service Center of Dashi Panyu, Guangzhou 511430, China. ^[2] State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen 361102, China. ^[3] The Second People's Hospital of Panyu Guangzhou, Guangzhou 511430, China. ^[4] Xingzhi College, Zhejiang Normal University, Lanxi 321004, China; College of Chemsitry and Bioengineering, Yichun 336000, China. ^[5] State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen 361102, China. Electronic address: fangmj@xmu.edu.cn. ^[6] State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen 361102, China. Electronic address: jzzeng@xmu.edu.cn. ^[7]

关键词 Anticancer activity Apoptosis Endoplasmic reticulum stress Indole derivatives Nur77 Target identification