An integrated investigation of mitochondrial genes in COPD reveals the causal effect of NDUFS2 by regulating pulmonary macrophages.

导出 OA

翻译打印收藏纠错

作者： Xiaoli,Zou ^[1] ; Qiqing,Huang ^[1] ; Tutu,Kang ^[1] ; Shaoran,Shen ^[1] ; Chenxi,Cao ^[1] ; Jianqing,Wu ^[2]

作者单位： Key Laboratory of Geriatrics of Jiangsu Province, Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu, China. ^[1] Key Laboratory of Geriatrics of Jiangsu Province, Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu, China. jwuny@njmu.edu.cn. ^[2]

关键词 COPD Least?absolute shrinkage and selection operator (LASSO)Macrophages Mendelian randomization (MR)Mitochondria NDUFS2 Random forest (RF)

主题词肺疾病, 慢性阻塞性(Pulmonary Disease, Chronic Obstructive);人类(Humans);小鼠(Mice);动物(Animals);巨噬细胞, 肺泡(Macrophages, Alveolar);基因, 线粒体(Genes, Mitochondrial);线粒体(Mitochondria)

DOI 10.1186/s13062-025-00593-3

PMID 39789601

发布时间 2025-01-12

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交