Dual inhibition of MAPK/ERK and BMP signaling induces entorhinal-like identity in mouse ESC-derived pallial progenitors.

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作者： Fabrizio,Tonelli ^[1] ; Ludovico,Iannello ^[2] ; Stefano,Gustincich ^[3] ; Angelo,Di Garbo ^[4] ; Luca,Pandolfini ^[5] ; Federico,Cremisi ^[6]

作者单位： Laboratorio di Biologia, Scuola Normale Superiore, 56126 Pisa, Italy. ^[1] Istituto di Biofisica, Consiglio Nazionale delle Ricerche, 56124 Pisa, Italy. ^[2] Center for Human Technologies, Central RNA Lab, Istituto Italiano di Tecnologia, 16152 Genova, Italy. ^[3] Istituto di Biofisica, Consiglio Nazionale delle Ricerche, 56124 Pisa, Italy; Dipartimento di Fisica, Università di Pisa, 56127 Pisa, Italy. ^[4] Center for Human Technologies, Central RNA Lab, Istituto Italiano di Tecnologia, 16152 Genova, Italy. Electronic address: luca.pandolfini@iit.it. ^[5] Laboratorio di Biologia, Scuola Normale Superiore, 56126 Pisa, Italy; Istituto di Biofisica, Consiglio Nazionale delle Ricerche, 56124 Pisa, Italy. Electronic address: federico.cremisi@sns.it. ^[6]

关键词 BMP HD-MEAs MAPK/ERK assembloids axonogenesis connectivity enthorinal cortex neural network pallium patterning theta activity

主题词动物(Animals);小鼠(Mice);骨形态发生蛋白质类(Bone Morphogenetic Proteins);内嗅皮层(Entorhinal Cortex);MAP激酶信号系统(MAP Kinase Signaling System);细胞分化(Cell Differentiation);信号传导(Signal Transduction);神经元(Neurons);基因表达调控, 发育期(Gene Expression Regulation, Developmental);神经干细胞(Neural Stem Cells)

DOI 10.1016/j.stemcr.2024.12.002

PMID 39793576

发布时间 2025-02-12

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Stem cell reports

2025年20卷2期

102387页

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Dual inhibition of MAPK/ERK and BMP signaling induces entorhinal-like identity in mouse ESC-derived pallial progenitors.

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Dual inhibition of MAPK/ERK and BMP signaling induces entorhinal-like identity in mouse ESC-derived pallial progenitors.

Stem cell reports

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Stem cell reports

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