Novel Nose-to-brain delivery of carbenoxolone via mucoadhesive solid lipid nanoparticles for Parkinson's symptoms management: In vitro and in vivo evaluation in a rotenone-induced rat model.

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第一作者： Hisham A,Nematalla

第一单位： Department of Pharmacology and Toxicology, Faculty of Pharmacy, Damanhour University, Damanhour 22511, Egypt.

作者： Hisham A,Nematalla ^[1] ; Mona,Elharoun ^[1] ; Somaia N,Bargash ^[1] ; Mohammad M,Abd-Alhaseeb ^[2] ; Hend A,Sharafeldin ^[3] ; Mariam,Zewail ^[4] ; Haidy,Abbas ^[4] ; Manal A,Elsheikh ^[5]

作者单位： Department of Pharmacology and Toxicology, Faculty of Pharmacy, Damanhour University, Damanhour 22511, Egypt. ^[1] Department of Pharmacology and Toxicology, Faculty of Pharmacy, Damanhour University, Damanhour 22511, Egypt; Department of Pharmacology, Larner College of Medicine, University of Vermont, Burlington, VT, USA. ^[2] Department of Pathology, Faculty of Medicine, Alexandria University, Alexandria 21131, Egypt. ^[3] Department of Pharmaceutics, Faculty of Pharmacy, Damanhour University, Damanhour 22511, Egypt. ^[4] Department of Pharmaceutics, Faculty of Pharmacy, Damanhour University, Damanhour 22511, Egypt. Electronic address: manal.elsheikh@pharm.dmu.edu.eg. ^[5]

关键词 Brain targeting Carbenoxolone Chitosan Neuroinflammation Parkinson’s disease Solid Lipid Nanocarriers

DOI 10.1016/j.ijpharm.2025.125197

PMID 39793636

发布时间 2025-01-14

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International journal of pharmaceutics

2025年670卷

125197页

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Novel Nose-to-brain delivery of carbenoxolone via mucoadhesive solid lipid nanoparticles for Parkinson's symptoms management: In vitro and in vivo evaluation in a rotenone-induced rat model.

International journal of pharmaceutics

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International journal of pharmaceutics

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Novel Nose-to-brain delivery of carbenoxolone via mucoadhesive solid lipid nanoparticles for Parkinson's symptoms management: In vitro and in vivo evaluation in a rotenone-induced rat model.

International journal of pharmaceutics

相似文献

International journal of pharmaceutics

相关期刊

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