Anticancer Plant Secondary Metabolites Evicting Linker Histone H1.2 from Chromatin Activate Type I Interferon Signaling.

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作者： Olga,Vlasova ^[1] ; Irina,Antonova ^[1] ; Khamis,Magomedova ^[1] ; Alena,Osipova ^[2] ; Polina,Shtompel ^[1] ; Anna,Borunova ^[1] ; Tatiana,Zabotina ^[1] ; Gennady,Belitsky ^[1] ; Irina,Budunova ^[3] ; Albert,Jordan ^[4] ; Kirill,Kirsanov ^[5] ; Marianna,Yakubovskaya ^[1]

作者单位： N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia, 24 Kashirskoe Shosse, 115522 Moscow, Russia. ^[1] N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia, 24 Kashirskoe Shosse, 115522 Moscow, Russia.;SBHI Moscow Clinical Scientific Center Named After Loginov MHD, 111123 Moscow, Russia. ^[2] Department of Dermatology, Northwestern University, Chicago, IL 60611, USA. ^[3] Institut de Biologia Molecular de Barcelona (IBMB-CSIC), 08028 Barcelona, Spain. ^[4] N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia, 24 Kashirskoe Shosse, 115522 Moscow, Russia.;Institute of Medicine, Peoples' Friendship University of Russia (RUDN University), Miklukho-Maklaya St. 6, 117198 Moscow, Russia. ^[5]

关键词 DNA-binding compounds LINE1 transcription anticancer effects chromatin structure double-stranded DNA ends linker histone eviction phytochemicals plant polyphenols plant secondary metabolites type I interferon signaling