首页> Molecular cell> RBBP6 anchors pre-mRNA 3' end processing to nuclear speckles for efficient gene expression.

RBBP6 anchors pre-mRNA 3' end processing to nuclear speckles for efficient gene expression.

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第一作者： Yoseop,Yoon

第一单位： Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA.

作者： Yoseop,Yoon ^[1] ; Elodie,Bournique ^[2] ; Lindsey V,Soles ^[1] ; Hong,Yin ^[3] ; Hsu-Feng,Chu ^[4] ; Christopher,Yin ^[5] ; Yinyin,Zhuang ^[6] ; Xiangyang,Liu ^[4] ; Liang,Liu ^[1] ; Joshua,Jeong ^[1] ; Clinton,Yu ^[7] ; Marielle,Valdez ^[1] ; Lusong,Tian ^[1] ; Lan,Huang ^[7] ; Xiaoyu,Shi ^[8] ; Georg,Seelig ^[9] ; Fangyuan,Ding ^[3] ; Liang,Tong ^[4] ; Rémi,Buisson ^[2] ; Yongsheng,Shi ^[10]

作者单位： Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA. ^[1] Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA. ^[2] Department of Biomedical Engineering, University of California, Irvine, Irvine, CA 92697, USA. ^[3] Department of Biological Sciences, Columbia University, New York, NY 10027, USA. ^[4] Department of Electrical and Computer Engineering, University of Washington, Seattle, Seattle, WA 98195, USA. ^[5] Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697, USA. ^[6] Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92697, USA. ^[7] Department of Biomedical Engineering, University of California, Irvine, Irvine, CA 92697, USA; Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697, USA; Department of Chemistry, University of California, Irvine, Irvine, CA 92697, USA. ^[8] Department of Electrical and Computer Engineering, University of Washington, Seattle, Seattle, WA 98195, USA; Paul G. Allen School of Computer Science and Engineering, University of Washington, Seattle, Seattle, WA 98195, USA. ^[9] Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA. Electronic address: yongshes@uci.edu. ^[10]

关键词 biomolecular condensate cleavage and polyadenylation gene expression intrinsically disordered region membraneless organelle nuclear speckle phase separation pre-mRNA 3′ end processing transcription termination

医学主题词人类(Humans);RNA前体(RNA Precursors);RNA剪接(RNA Splicing);细胞核(Cell Nucleus);RNA聚合酶Ⅱ(RNA Polymerase II);RNA3'端加工(RNA 3' End Processing);RNA, 信使(RNA, Messenger);HEK293细胞(HEK293 Cells);蛋白质结合(Protein Binding);RNA加工, 转录后(RNA Processing, Post-Transcriptional);基因表达调控(Gene Expression Regulation);RNA结合蛋白质类(RNA-Binding Proteins)

DOI 10.1016/j.molcel.2024.12.016

PMID 39798570

发布时间 2026-02-07

基金项目

R21 AI185033/AI/NIAID NIH HHS/United States DP2 GM150017/GM/NIGMS NIH HHS/United States R35 GM149294/GM/NIGMS NIH HHS/United States R21 ES036190/ES/NIEHS NIH HHS/United States P30 CA062203/CA/NCI NIH HHS/United States R35 GM118093/GM/NIGMS NIH HHS/United States R37 CA252081/CA/NCI NIH HHS/United States R01 AI170840/AI/NIAID NIH HHS/United States S10 OD032327/OD/NIH HHS/United States R35 GM145249/GM/NIGMS NIH HHS/United States

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