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Single-cell RNA-seq identifies protracted mouse germline X chromosome reactivation dynamics directed by a PRC2-dependent mechanism.

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第一作者： Yaqiong,Liu

第一单位： King's College London, Centre for Gene Therapy and Regenerative Medicine, School of Basic & Medical Biosciences, Faculty of Life Sciences and Medicine, London, UK.

作者： Yaqiong,Liu ^[1] ; Xianzhong,Lau ^[2] ; Prabhakaran,Munusamy ^[2] ; Carlos M Abascal Sherwell,Sanchez ^[1] ; Daniel,Snell ^[3] ; Mahesh,Sangrithi ^[4]

作者单位： King's College London, Centre for Gene Therapy and Regenerative Medicine, School of Basic & Medical Biosciences, Faculty of Life Sciences and Medicine, London, UK. ^[1] KK Women's and Children Hospital, Division of Obstetrics and Gynaecology, Singapore, Singapore. ^[2] Francis Crick Institute, London, UK. ^[3] King's College London, Centre for Gene Therapy and Regenerative Medicine, School of Basic & Medical Biosciences, Faculty of Life Sciences and Medicine, London, UK; King's College London, Guy's Hospital Assisted Conception Unit, Department of Women and Children's Health, School of Life Course and Population Sciences, Faculty of Life Sciences and Medicine, London, UK. Electronic address: mahesh.sangrithi@kcl.ac.uk. ^[4]

关键词 PRC2 X chromosome reactivation allele-specific expression dosage compensation genome-wide reprogramming germ cells single-cell RNA-seq