NADH-bound AIF activates the mitochondrial CHCHD4/MIA40 chaperone by a substrate-mimicry mechanism.

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作者： Chris A,Brosey ^[1] ; Runze,Shen ^[1] ; John A,Tainer ^[2]

作者单位： Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 77030, USA. ^[1] Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 77030, USA. JTainer@mdanderson.org.;Department of Cancer Biology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 77030, USA. JTainer@mdanderson.org.;MBIB Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA. JTainer@mdanderson.org. ^[2]

关键词 Apoptosis-inducing Factor (AIF)CHCHD4/MIA40 OXPHOS Small-angle X-ray Scattering (SAXS)X-ray Crystallography

DOI 10.1038/s44318-024-00360-6

PMID 39806100

发布时间 2025-01-13

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NADH-bound AIF activates the mitochondrial CHCHD4/MIA40 chaperone by a substrate-mimicry mechanism.

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NADH-bound AIF activates the mitochondrial CHCHD4/MIA40 chaperone by a substrate-mimicry mechanism.

The EMBO journal

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The EMBO journal

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