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Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis.

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第一作者： Joan,Chang

第一单位： Wellcome Centre for Cell-Matrix Research, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.;Division of Molecular and Cellular Function, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.

作者： Joan,Chang ^[1] ; Adam,Pickard ^[2] ; Jeremy A,Herrera ^[2] ; Sarah,O'Keefe ^[3] ; Richa,Garva ^[2] ; Matthew,Hartshorn ^[2] ; Anna,Hoyle ^[2] ; Lewis,Dingle ^[4] ; John,Knox ^[1] ; Thomas A,Jowitt ^[2] ; Madeleine,Coy ^[3] ; Jason,Wong ^[4] ; Adam,Reid ^[4] ; Yinhui,Lu ^[2] ; Cédric,Zeltz ^[5] ; Rajamiyer V,Venkateswaran ^[6] ; Patrick T,Caswell ^[2] ; Stephen,High ^[3] ; Donald,Gullberg ^[5] ; Karl E,Kadler ^[2]

作者单位： Wellcome Centre for Cell-Matrix Research, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.;Division of Molecular and Cellular Function, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom. ^[1] Wellcome Centre for Cell-Matrix Research, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom. ^[2] Division of Molecular and Cellular Function, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom. ^[3] Blond McIndoe Laboratories, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom. ^[4] Department of Biomedicine and Centre for Cancer Biomarkers, Norwegian Center of Excellence, University of Bergen, Bergen, Norway. ^[5] Manchester University National Health Service Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom. ^[6]

关键词 cell biology collagen endocytosis fibrillogenesis fibrosis human integrin mouse

医学主题词人类(Humans);胞吞作用(Endocytosis);成纤维细胞(Fibroblasts);膜泡运输蛋白质类(Vesicular Transport Proteins);纤维化(Fibrosis);胶原Ⅰ型(Collagen Type I);昼夜节律(Circadian Rhythm)

DOI 10.7554/eLife.95842

PMID 39812558

发布时间 2025-05-01

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