Dendritic Platinum Nanoparticles Shielded by Pt-S PEGylation as Intracellular Reactors for Bioorthogonal Uncaging Chemistry.

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第一作者： Jose I,Garcia-Peiro

第一单位： Instituto de Nanociencia y Materiales de Aragon (INMA), CSIC-Universidad de Zaragoza, Edificio I+D, C/Poeta Mariano Esquillor s/n, 50018, Zaragoza, Spain.;Department of Chemical and Environmental Engineering, University of Zaragoza, Campus Rio Ebro, C/María de Luna, 3, 50018, Zaragoza, Spain.;Networking Research Center in Biomaterials, Bioengineering and Nanomedicine (CIBER-BBN), Instituto de Salud Carlos III, 28029, Madrid, Spain.;Instituto de Investigación Sanitaria (IIS) de Aragón, Avenida San Juan Bosco, 13, 50009, Zaragoza, Spain.

作者： Jose I,Garcia-Peiro ^[1] ; M Carmen,Ortega-Liebana ^[2] ; Catherine,Adam ^[3] ; Álvaro,Lorente-Macías ^[3] ; Jana,Travnickova ^[4] ; E Elizabeth,Patton ^[4] ; Paula,Guerrero-López ^[5] ; J Manuel,Garcia-Aznar ^[5] ; Jose L,Hueso ^[6] ; Jesus,Santamaria ^[1] ; Asier,Unciti-Broceta ^[3]

作者单位： Instituto de Nanociencia y Materiales de Aragon (INMA), CSIC-Universidad de Zaragoza, Edificio I+D, C/Poeta Mariano Esquillor s/n, 50018, Zaragoza, Spain.;Department of Chemical and Environmental Engineering, University of Zaragoza, Campus Rio Ebro, C/María de Luna, 3, 50018, Zaragoza, Spain.;Networking Research Center in Biomaterials, Bioengineering and Nanomedicine (CIBER-BBN), Instituto de Salud Carlos III, 28029, Madrid, Spain.;Instituto de Investigación Sanitaria (IIS) de Aragón, Avenida San Juan Bosco, 13, 50009, Zaragoza, Spain. ^[1] Edinburgh Cancer Research, Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Crewe Road South, Edinburgh, EH4 2XR, UK.;Department of Medicinal and Organic Chemistry and Unit of Excellence in Chemistry Applied to Biomedicine and Environment, Faculty of Pharmacy, Campus Cartuja s/n, University of Granada, 18071, Granada, Spain.;GENYO, Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Avda. Ilustración 114, 18016, Granada, Spain.;Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain. ^[2] Edinburgh Cancer Research, Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Crewe Road South, Edinburgh, EH4 2XR, UK. ^[3] Edinburgh Cancer Research, Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Crewe Road South, Edinburgh, EH4 2XR, UK.;MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Crewe Road South, Edinburgh, EH4 2XR, UK. ^[4] Instituto de Investigación Sanitaria (IIS) de Aragón, Avenida San Juan Bosco, 13, 50009, Zaragoza, Spain.;Multiscale in Mechanical and Biological Engineering (M2BE), Aragon Institute of Engineering Research (I3 A), University of Zaragoza, Mariano Esquillor s/n, 50018, Zaragoza, Spain. ^[5] Instituto de Nanociencia y Materiales de Aragon (INMA), CSIC-Universidad de Zaragoza, Edificio I+D, C/Poeta Mariano Esquillor s/n, 50018, Zaragoza, Spain.;Department of Chemical and Environmental Engineering, University of Zaragoza, Campus Rio Ebro, C/María de Luna, 3, 50018, Zaragoza, Spain.;Networking Research Center in Biomaterials, Bioengineering and Nanomedicine (CIBER-BBN), Instituto de Salud Carlos III, 28029, Madrid, Spain.;Instituto de Investigación Sanitaria (IIS) de Aragón, Avenida San Juan Bosco, 13, 50009, Zaragoza, Spain.;Escuela Politécnica Superior, Universidad de Zaragoza. Crta. de Cuarte s/n, 22071, Huesca, Spain. ^[6]

关键词 anticancer drugs bioorthogonal catalysis heterogeneous platinum