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Synthesis and biological assessment of BUB1B inhibitors for the treatment of clear cell renal cell carcinoma.

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第一作者： Mohamed,El Hafi

第一单位： Trustlife Labs Drug Research & Development Center, 34774, Istanbul, Turkey; Faculty of Medicine and Pharmacy, Mohammed First University, Oujda, Morocco.

作者： Mohamed,El Hafi ^[1] ; Younos,Bouzian ^[2] ; Negar,Parvizi ^[2] ; Woonghee,Kim ^[3] ; Mine,Subaşioğlu ^[2] ; Mehmet,Ozcan ^[4] ; Hasan,Turkez ^[5] ; Adil,Mardinoglu ^[6]

作者单位： Trustlife Labs Drug Research & Development Center, 34774, Istanbul, Turkey; Faculty of Medicine and Pharmacy, Mohammed First University, Oujda, Morocco. ^[1] Trustlife Labs Drug Research & Development Center, 34774, Istanbul, Turkey. ^[2] Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, SE, 17165, Sweden. ^[3] Department of Medical Biochemistry, Faculty of Medicine, Zonguldak Bulent Ecevit University, Zonguldak, Turkey. ^[4] Department of Medical Biology, Faculty of Medicine, Atatürk University, Erzurum, Turkey. ^[5] Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, SE, 17165, Sweden; Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, SE1 9RT, UK. Electronic address: adilm@scilifelab.se. ^[6]

关键词 BUB1B Caki-1 Drug design Structure-activity relationship TG-101209 ccRCC