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Humanized Candida and NanoBiT Assays Expedite Discovery of Bdf1 Bromodomain Inhibitors With Antifungal Potential.

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第一作者： Kaiyao,Wei

第一单位： Univ. Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale (IBS), Grenoble, 38000, France.;Univ. Grenoble Alpes, Inserm, CNRS, Institute for Advanced Biosciences (IAB), Grenoble, 38000, France.

作者： Kaiyao,Wei ^[1] ; Marie,Arlotto ^[2] ; Justin M,Overhulse ^[3] ; Tuan-Anh,Dinh ^[4] ; Yingsheng,Zhou ^[3] ; Nathan J,Dupper ^[3] ; Jiayi,Yang ^[3] ; Boris A,Kashemirov ^[3] ; Hasan,Dawi ^[5] ; Cécile,Garnaud ^[4] ; Gaëlle,Bourgine ^[6] ; Flore,Mietton ^[5] ; Morgane,Champleboux ^[2] ; Amédé,Larabi ^[5] ; Yordan,Hayat ^[5] ; Rose-Laure,Indorato ^[5] ; Marjolaine,Noirclerc-Savoye ^[5] ; Dimitrios,Skoufias ^[5] ; Muriel,Cornet ^[4] ; Gwenaël,Rabut ^[6] ; Charles E,McKenna ^[3] ; Carlo,Petosa ^[5] ; Jérôme,Govin ^[2]

作者单位： Univ. Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale (IBS), Grenoble, 38000, France.;Univ. Grenoble Alpes, Inserm, CNRS, Institute for Advanced Biosciences (IAB), Grenoble, 38000, France. ^[1] Univ. Grenoble Alpes, Inserm, CNRS, Institute for Advanced Biosciences (IAB), Grenoble, 38000, France. ^[2] Department of Chemistry, Dana and David Dornsife College of Letters, Arts, and Sciences, University of Southern California, University Park Campus, Los Angeles, CA, 90089, USA. ^[3] Univ. Grenoble Alpes, CNRS, Grenoble INP, CHU Grenoble Alpes, Laboratoire TIMC, Grenoble, 38000, France. ^[4] Univ. Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale (IBS), Grenoble, 38000, France. ^[5] Univ. Rennes, CNRS, INSERM, Institut de Génétique et Développement de Rennes (IGDR), UMR 6290, U1305, Rennes, 35000, France. ^[6]

关键词 BET inhibition Bdf1 Candida antifungal bromodomain