mtSTAT3 suppresses rheumatoid arthritis by regulating Th17 and synovial fibroblast inflammatory cell death with IL-17-mediated autophagy dysfunction.
第一作者:
Seon-Yeong,Lee
第一单位:
Lab of Translational ImmunoMedicine, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.;Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
作者:
医学主题词
动物(Animals);关节炎, 类风湿(Arthritis, Rheumatoid);Th17细胞(Th17 Cells);自噬(Autophagy);人类(Humans);小鼠(Mice);白细胞介素17(Interleukin-17);成纤维细胞(Fibroblasts);STAT3转录因子(STAT3 Transcription Factor);关节炎, 实验性(Arthritis, Experimental);疾病模型, 动物(Disease Models, Animal);男(雄)性(Male);滑膜(Synovial Membrane);线粒体(Mitochondria);小鼠, 近交DBA(Mice, Inbred DBA)
DOI
10.1038/s12276-024-01376-y
PMID
39825104
发布时间
2025-05-01
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