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PRMT5 inhibition reduces hyperinflammation in a murine model of secondary hemophagocytic lymphohistiocytosis.

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第一作者： Fiona,Brown-Burke

第一单位： Division of Hematology, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH.

作者： Fiona,Brown-Burke ^[1] ; Rachel,Saadey ^[1] ; Hsiao-Yin Charlene,Mao ^[1] ; Paola,Marra ^[1] ; Eric,Brooks ^[1] ; Alexa,Wandtke ^[1] ; Ian,Hout ^[1] ; Sydney,Leon ^[1] ; Archisha,Sharma ^[1] ; Aneeq,Yasin ^[1] ; Taylor,Cash ^[1] ; Elshafa Hassan,Ahmed ^[2] ; Ethan,Baiocchi ^[1] ; Stephanie,Finoti ^[1] ; Xiaoli,Zhang ^[3] ; Neha,Bhagwat ^[4] ; Kris,Vaddi ^[4] ; Peggy,Scherle ^[4] ; Anna,Mozhenkova ^[1] ; Ikbale,El-Ayachi ^[5] ; Austin D,Schenk ^[5] ; Shelby L,Sloan ^[2] ; Kaylee,Whitman ^[1] ; JoBeth,Helmig-Mason ^[1] ; Sheldon,Steyn ^[1] ; Haley L,Klimaszewski ^[1] ; Jessica,Weist ^[1] ; Christoph,Weigel ^[1] ; Shirsha,Koirala ^[1] ; Lapo,Alinari ^[1] ; Katiri,Snyder ^[1] ; Parvathi,Ranganathan ^[1] ; Chia-Jo,Chen ^[6] ; Michael B,Jordan ^[6] ; Robert A,Baiocchi ^[1] ; Polina,Shindiapina ^[1]

作者单位： Division of Hematology, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH. ^[1] Division of Hematology, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH.;Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH. ^[2] Department of Biomedical Informatics, The Ohio State University, Columbus, OH. ^[3] Prelude Therapeutics, Wilmington, DE. ^[4] Division of Transplantation Surgery, The Ohio State University Wexner Medical, Columbus, OH. ^[5] Department of Pediatrics, University of Cincinnati, Cincinnati, OH. ^[6]

医学主题词动物(Animals);蛋白质精氨酸N-甲基转移酶(Protein-Arginine N-Methyltransferases);淋巴组织细胞增多症, 嗜血细胞性(Lymphohistiocytosis, Hemophagocytic);小鼠(Mice);疾病模型, 动物(Disease Models, Animal);炎症(Inflammation);细胞因子类(Cytokines);杀伤细胞, 天然(Killer Cells, Natural);酶抑制剂(Enzyme Inhibitors);T淋巴细胞(T-Lymphocytes)

DOI 10.1182/bloodadvances.2024013651

PMID 39825858

发布时间 2025-07-10

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Blood advances

2025年9卷10期

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2025年9卷10期

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PRMT5 inhibition reduces hyperinflammation in a murine model of secondary hemophagocytic lymphohistiocytosis.

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PRMT5 inhibition reduces hyperinflammation in a murine model of secondary hemophagocytic lymphohistiocytosis.

Blood advances

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Blood advances

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