Targeting the mitotic kinase NEK2 enhances CDK4/6 inhibitor efficacy by potentiating genome instability.

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第一作者： Jessica R,Bobbitt

第一单位： Department of Pathology School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA.

作者： Jessica R,Bobbitt ^[1] ; Leslie,Cuellar-Vite ^[2] ; Kristen L,Weber-Bonk ^[3] ; Marlee R,Yancey ^[4] ; Parth R,Majmudar ^[2] ; Ruth A,Keri ^[5]

作者单位： Department of Pathology School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA; Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA. ^[1] Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA; Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA. ^[2] Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA. ^[3] Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA. ^[4] Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA. Electronic address: Kerir@ccf.org. ^[5]

关键词 CDK4/6 inhibitors NEK2 breast cancer cell cycle cell death combination therapy genomic instability mitosis mitotic catastrophe

DOI 10.1016/j.jbc.2025.108196

PMID 39826695

发布时间 2025-02-09

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