Advances in the structural understanding of opioid allostery.

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作者： Nokomis,Ramos-Gonzalez ^[1] ; Balazs R,Varga ^[1] ; Susruta,Majumdar ^[2]

作者单位： Department of Anesthesiology and Washington University Pain Center, Washington University School of Medicine, St Louis, MO, USA; Center for Clinical Pharmacology, Washington University School of Medicine, St Louis, MO, USA. ^[1] Department of Anesthesiology and Washington University Pain Center, Washington University School of Medicine, St Louis, MO, USA; Center for Clinical Pharmacology, Washington University School of Medicine, St Louis, MO, USA. Electronic address: susrutam@wustl.edu. ^[2]

关键词 allostery negative allosteric modulator opioid positive allosteric modulator sodium binding site μ-opioid receptor

主题词人类(Humans);别构调节(Allosteric Regulation);受体, 阿片样, μ(Receptors, Opioid, mu);镇痛药, 阿片类(Analgesics, Opioid);动物(Animals);别构部位(Allosteric Site)

DOI 10.1016/j.tips.2024.12.007

PMID 39827063

发布时间 2025-02-08

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