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A multicenter Phase II randomized, placebo-controlled single-blind trial with the SV2A ligand seletracetam in photosensitive epilepsy patients.

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第一作者： Dorothee,Kasteleijn-Nolst Trenité

第一单位： Department of Neurosurgery and Epilepsy, University Medical Center Utrecht, Utrecht, the Netherlands; Nesmos Department, Faculty of Medicine and Psychology, Sapienza University, Roma, Italy. Electronic address: dkasteleijn@planet.nl.

作者： Dorothee,Kasteleijn-Nolst Trenité ^[1] ; Armel,Stockis ^[2] ; Edouard,Hirsch ^[3] ; Pierre,Genton ^[4] ; Bassel W,Abou-Khalil ^[5] ; Jacqueline A,French ^[6] ; Pascal,Masnou ^[7] ; Wolfgang,Löscher ^[8]

作者单位： Department of Neurosurgery and Epilepsy, University Medical Center Utrecht, Utrecht, the Netherlands; Nesmos Department, Faculty of Medicine and Psychology, Sapienza University, Roma, Italy. Electronic address: dkasteleijn@planet.nl. ^[1] UCB Pharma, Braine-l'Alleud, Belgium. ^[2] Epilepsy Unit "Francis Rohmer," ERN EpiCare, French Centre de Référence des Épilepsies Rares (CréER), Neurology Department, Hôpitaux Universitaires de Strasbourg, Strasbourg, France. ^[3] Neurology Department, Centre Hospitalier du Pays d'Aix, Aix-en-Provence, France. ^[4] Department of Neurology, Vanderbilt University, Nashville, TN, USA. ^[5] Comprehensive Epilepsy Center, New York University Langone Medical Center, New York, USA. ^[6] Department of Neurology, University Hospital Kremlin-Bicêtre, Paris, France. ^[7] Translational Neuropharmacology Lab, NIFE, Department of Experimental Otology of the ENT Clinics, Hannover Medical School, Hannover, Germany. Electronic address: Loescher.Wolfgang@mh-hannover.de. ^[8]

关键词 Antiseizure medication Pharmacodynamics Pharmacokinetics Photosensitivity model Safety