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Targeting aldolase A in hepatocellular carcinoma leads to imbalanced glycolysis and energy stress due to uncontrolled FBP accumulation.

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作者单位: Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany. [1] Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany.;Faculty of Biosciences, Heidelberg University, Heidelberg, Germany. [2] Institute for Theoretical Biology, Humboldt University of Berlin, Berlin, Germany. [3] Department of Biochemistry and Molecular Biology, Theodor-Boveri-Institute, University of Würzburg, Würzburg, Germany. [4] Department of Medical Oncology and Pneumology, University Hospital Tübingen, Tübingen, Germany.;IFIT Cluster of Excellence EXC 2180 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen, Germany. [5] Department of Biochemistry and Molecular Biology, Theodor-Boveri-Institute, University of Würzburg, Würzburg, Germany.;Biochemical Institute, University of Kiel, Kiel, Germany. [6] Department of Medical Oncology and Pneumology, University Hospital Tübingen, Tübingen, Germany.;IFIT Cluster of Excellence EXC 2180 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen, Germany.;Tübingen Center for Academic Drug Discovery & Development (TüCAD2), Tübingen, Germany. [7] Institute for Theoretical Biology, Humboldt University of Berlin, Berlin, Germany.;Peter Debye Institute for Soft Matter Physics, Leipzig University, Leipzig, Germany. [8] Division of Tumor Metabolism and Microenvironment, German Cancer Research Center (DKFZ), Heidelberg, Germany. almut.schulze@dkfz-heidelberg.de. [9]
DOI 10.1038/s42255-024-01201-w
PMID 39833612
发布时间 2025-01-20
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