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Development of compounds for targeted degradation of mammalian cryptochrome proteins.

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第一作者： Jack,Munns

第一单位： MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.

作者： Jack,Munns ^[1] ; Andrew D,Beale ^[1] ; Iacovos N,Michaelides ^[2] ; Sew Y,Peak-Chew ^[1] ; Andrei,Mihut ^[1] ; Christine T,Major-Styles ^[3] ; Aiwei,Zeng ^[3] ; R Ian,Storer ^[2] ; Rachel S,Edgar ^[3] ; Kevin,Moreau ^[4] ; John S,O'Neill ^[1]

作者单位： MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK. ^[1] Hit Discovery, Discovery Sciences, R&D, AstraZeneca, Cambridge CB2 0AA, UK. ^[2] Department of Infectious Disease, Imperial College London, London W2 1NY, UK.;Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK. ^[3] Safety Sciences, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Cambridge CB2 0AA, UK. ^[4]

关键词 PROTAC cellular physiology circadian rhythms cryptochromes mass spectrometry protein degradation

医学主题词隐花色素类(Cryptochromes);动物(Animals);人类(Humans);昼夜节律(Circadian Rhythm)

DOI 10.1098/rstb.2023.0342

PMID 39842482

发布时间 2025-05-02

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Philosophical transactions of the Royal Society of London. Series B, Biological sciences

2025年380卷1918期

20230342页

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Philosophical transactions of the Royal Society of London. Series B, Biological sciences

2025年380卷1918期

20230342页

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Development of compounds for targeted degradation of mammalian cryptochrome proteins.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences

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Philosophical transactions of the Royal Society of London. Series B, Biological sciences

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Development of compounds for targeted degradation of mammalian cryptochrome proteins.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences

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Philosophical transactions of the Royal Society of London. Series B, Biological sciences

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