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WT1-mRNA dendritic cell vaccination of patients with glioblastoma multiforme, malignant pleural mesothelioma, metastatic breast cancer, and other solid tumors: type 1 T-lymphocyte responses are associated with clinical outcome.

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第一作者: Zwi N,Berneman
第一单位: Center for Cell Therapy & Regenerative Medicine (CCRG), Antwerp University Hospital (UZA), Edegem, Belgium. zwi.berneman@uza.be.;Division of Hematology & Multidisciplinary Oncological Center Antwerp (MOCA), Antwerp University Hospital, Edegem, Belgium. zwi.berneman@uza.be.;Laboratory of Experimental Hematology, Vaccine and Infectious Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium. zwi.berneman@uza.be.
作者单位: Center for Cell Therapy & Regenerative Medicine (CCRG), Antwerp University Hospital (UZA), Edegem, Belgium. zwi.berneman@uza.be.;Division of Hematology & Multidisciplinary Oncological Center Antwerp (MOCA), Antwerp University Hospital, Edegem, Belgium. zwi.berneman@uza.be.;Laboratory of Experimental Hematology, Vaccine and Infectious Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium. zwi.berneman@uza.be. [1] Center for Cell Therapy & Regenerative Medicine (CCRG), Antwerp University Hospital (UZA), Edegem, Belgium. maxime.delaere@uza.be.;Division of Hematology & Multidisciplinary Oncological Center Antwerp (MOCA), Antwerp University Hospital, Edegem, Belgium. maxime.delaere@uza.be.;Laboratory of Experimental Hematology, Vaccine and Infectious Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium. maxime.delaere@uza.be. [2] Department of Pneumology, Maria Middelares General Hospital, Ghent, Belgium. [3] Division of Oncology & Multidisciplinary Oncological Center Antwerp, Antwerp University Hospital, Edegem, Belgium.;Bio and Tissue Bank, Antwerp University Hospital, Edegem, Belgium.;Department of Antwerp Surgical Training, Anatomy and Research Centre (ASTARC), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium. [4] Center for Cell Therapy & Regenerative Medicine (CCRG), Antwerp University Hospital (UZA), Edegem, Belgium.;Laboratory of Experimental Hematology, Vaccine and Infectious Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.;Division of Oncology & Multidisciplinary Oncological Center Antwerp, Antwerp University Hospital, Edegem, Belgium.;Center for Oncological Research (CORE), Integrated Personalized and Precision Oncology Network (IPPON), Department of Molecular Imaging, Pathology, Radiotherapy and Oncology (MIPRO), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium. [5] Center for Cell Therapy & Regenerative Medicine (CCRG), Antwerp University Hospital (UZA), Edegem, Belgium.;Laboratory of Experimental Hematology, Vaccine and Infectious Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium. [6] Division of Oncology & Multidisciplinary Oncological Center Antwerp, Antwerp University Hospital, Edegem, Belgium.;Center for Oncological Research (CORE), Integrated Personalized and Precision Oncology Network (IPPON), Department of Molecular Imaging, Pathology, Radiotherapy and Oncology (MIPRO), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium. [7] Center for Oncological Research (CORE), Integrated Personalized and Precision Oncology Network (IPPON), Department of Molecular Imaging, Pathology, Radiotherapy and Oncology (MIPRO), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.;Division of Gynecological Oncology & Multidisciplinary Oncological Center Antwerp, Antwerp University Hospital, Edegem, Belgium. [8] Center for Cell Therapy & Regenerative Medicine (CCRG), Antwerp University Hospital (UZA), Edegem, Belgium.;Laboratory of Experimental Hematology, Vaccine and Infectious Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.;Bio and Tissue Bank, Antwerp University Hospital, Edegem, Belgium.;Clinical Research Center (CRC) Antwerp, Antwerp University Hospital, Edegem, Belgium. [9] Center for Cell Therapy & Regenerative Medicine (CCRG), Antwerp University Hospital (UZA), Edegem, Belgium.;Laboratory of Experimental Hematology, Vaccine and Infectious Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.;Bio and Tissue Bank, Antwerp University Hospital, Edegem, Belgium. [10] Center for Cell Therapy & Regenerative Medicine (CCRG), Antwerp University Hospital (UZA), Edegem, Belgium.;Division of Hematology & Multidisciplinary Oncological Center Antwerp (MOCA), Antwerp University Hospital, Edegem, Belgium.;Laboratory of Experimental Hematology, Vaccine and Infectious Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.;Bio and Tissue Bank, Antwerp University Hospital, Edegem, Belgium. [11] Division of Radiology, Antwerp University Hospital, Edegem, Belgium.;Department of Molecular Morphology and Microscopy (mVISION), Faculty of Medicine and Medical Sciences, University of Antwerp, Antwerp, Belgium. [12] Division of Radiology, Antwerp University Hospital, Edegem, Belgium. [13] Division of Hematology & Multidisciplinary Oncological Center Antwerp (MOCA), Antwerp University Hospital, Edegem, Belgium. [14] Center for Cell Therapy & Regenerative Medicine (CCRG), Antwerp University Hospital (UZA), Edegem, Belgium.;Division of Hematology & Multidisciplinary Oncological Center Antwerp (MOCA), Antwerp University Hospital, Edegem, Belgium. [15] Center for Oncological Research (CORE), Integrated Personalized and Precision Oncology Network (IPPON), Department of Molecular Imaging, Pathology, Radiotherapy and Oncology (MIPRO), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.;Division of Anatomopathology, Antwerp University Hospital, Edegem, Belgium. [16] Centre for the Evaluation of Vaccination (CEV), Vaccine and Infectious Disease Institute, Faculty of Medicine and Medical Sciences, University of Antwerp, Antwerp, Belgium. [17] Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK. [18] Division of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK.;Systems Immunity Research Institute, Cardiff University School of Medicine, Cardiff, UK. [19] Department of Cancer Stem Cell Biology, Osaka University Graduate School of Medicine, Osaka, Japan. [20] Department of Clinical Laboratory and Biomedical Sciences, Integrated Health Design Initiative (IHDi), Osaka University Graduate School of Medicine, Osaka, Japan. [21] Department of Cancer Immunology, Osaka University Graduate School of Medicine, Osaka, Japan. [22] Division of Nephrology, Antwerp University Hospital, Edegem, Belgium.;Department of Translational Research in Immunology and Inflammation (TWI2N), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium. [23] Center for Cell Therapy & Regenerative Medicine (CCRG), Antwerp University Hospital (UZA), Edegem, Belgium.;Division of Hematology & Multidisciplinary Oncological Center Antwerp (MOCA), Antwerp University Hospital, Edegem, Belgium.;Laboratory of Experimental Hematology, Vaccine and Infectious Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium. [24] Center for Cell Therapy & Regenerative Medicine (CCRG), Antwerp University Hospital (UZA), Edegem, Belgium.;Center for Oncological Research (CORE), Integrated Personalized and Precision Oncology Network (IPPON), Department of Molecular Imaging, Pathology, Radiotherapy and Oncology (MIPRO), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium. [25]
DOI 10.1186/s13045-025-01661-x
PMID 39849594
发布时间 2025-07-28
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Journal of hematology & oncology

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